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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Suv39h2tm1Jnw
targeted mutation 1, Thomas Jenuwein
MGI:2445450
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Suv39h2tm1Jnw/Suv39h2tm1Jnw involves: 129 * C57BL/6J MGI:3033492
ht2
 		Suv39h2tm1Jnw/Suv39h2+ involves: 129 * C57BL/6J MGI:3033493
cx3
 		Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2tm1Jnw 		involves: 129 * C57BL/6J MGI:3033496
cx4
 		Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2+ 		involves: 129 * C57BL/6J MGI:3033497
cx5
 		Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2+ 		involves: 129 * C57BL/6J MGI:3033498
cx6
 		Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2tm1Jnw 		involves: 129 * C57BL/6J MGI:3033499


Genotype
MGI:3033492
hm1
Allelic
Composition		 Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in less than 5% of mice compared to controls




Genotype
MGI:3033493
ht2
Allelic
Composition		 Suv39h2tm1Jnw/Suv39h2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in less than 5% of mice compared to controls




Genotype
MGI:3033496
cx3
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (9 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:72503 )
• incomplete penetrance; more than half of double homozyous animals die before birth

embryo
decreased embryo size ( J:72503 )
• double homozygous embryos are smaller than controls

growth/size/body
decreased embryo size ( J:72503 )
• double homozygous embryos are smaller than controls
postnatal growth retardation ( J:72503 )

reproductive system
arrest of male meiosis ( J:72503 )
• spermatogenesis in impaired with an arrest of differentiation at the transition stage between early and late spermatocytes; an accumulation of preleptotene spermatocytes and the appearance of apoptotic mid to late pachytene spermatocytes with meiotic defects were noted
small gonad ( J:72503 )
• male hypogonadism was noted in mice surviving past birth




Genotype
MGI:3033497
cx4
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (9 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in 28% of mice compared to controls




Genotype
MGI:3033498
cx5
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (9 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in 28% of mice compared to controls




Genotype
MGI:3033499
cx6
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (9 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in less than 5% of mice compared to controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory