Phenotypes associated with this allele

• Allele Symbol: Rr349^tm1.1Wgw
• Allele Name: targeted mutation 1.1, William G Wood
• Allele ID: MGI:2445400
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr349^tm1.1Wgw/Rr349^tm1.1Wgw	involves: 129P2/OlaHsd * CD-1	MGI:3721071
ht2	Rr349^tm1.1Wgw/Rr349^+	involves: 129P2/OlaHsd * CD-1	MGI:3721069
cx3	Rr348^tm1.1Drhi/Rr348^tm1.1Drhi Rr349^tm1.1Wgw/Rr349^tm1.1Wgw	involves: 129P2/OlaHsd	MGI:7433188
cx4	Rr348^tm1.1Drhi/Rr348^+ Rr349^tm1.1Wgw/Rr349^+	Not Specified	MGI:7433190

Genotype
MGI:3721071

hm1

• Allelic Composition: Rr349^tm1.1Wgw/Rr349^tm1.1Wgw
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal erythropoiesis ( J:80121 )

• increase in erythroid precursors in the spleen

abnormal hemoglobin ( J:80121 )

• ratio of alpha-globin RNA to beta-globin RNA was reduced in fetal livers, adult spleens and bone marrow, but not in peripheral blood in embryos and adults

decreased mean corpuscular hemoglobin ( J:80121 )

• reduced compared with those in heterozygotes and normal controls

• normal levels of hemoglobin, however under experimentally induced hemolytic anemia condition, level of hemoglobin was lower in homozygous compared to control

• fully viable and fertile

decreased mean corpuscular volume ( J:80121 )

• reduced compared with those in heterozygotes and normal controls

Genotype
MGI:3721069

ht2

• Allelic Composition: Rr349^tm1.1Wgw/Rr349⁺
• Genetic Background: involves: 129P2/OlaHsd * CD-1

hematopoietic system

decreased mean corpuscular hemoglobin ( J:80121 )

• slightly reduced

• essentially normal levels of hemoglobin

• level of alpha globin mRNA were also minimally reduced in the peripheral blood

decreased mean corpuscular volume ( J:80121 )

• slightly reduced

Genotype
MGI:7433188

cx3

• Allelic Composition: Rr348^tm1.1Drhi/Rr348^tm1.1Drhi; Rr349^tm1.1Wgw/Rr349^tm1.1Wgw
• Genetic Background: involves: 129P2/OlaHsd

cardiovascular system

hemorrhage ( J:259286 )

• in E14.5 embryos

embryo

decreased embryo size ( J:259286 )

• E14.5 embryos

growth/size/body

decreased embryo size ( J:259286 )

• E14.5 embryos

nuchal edema ( J:259286 )

• in E14.5 embryos

homeostasis/metabolism

nuchal edema ( J:259286 )

• in E14.5 embryos

integument

nuchal edema ( J:259286 )

• in E14.5 embryos

pallor ( J:259286 )

• in E14.5 embryos

mortality/aging

prenatal lethality, complete penetrance ( J:259286 )

• no homozygous mice born

Genotype
MGI:7433190

cx4

• Allelic Composition: Rr348^tm1.1Drhi/Rr348⁺; Rr349^tm1.1Wgw/Rr349⁺
• Genetic Background: Not Specified

hematopoietic system

decreased mean corpuscular hemoglobin ( J:259286 )

decreased mean corpuscular volume ( J:259286 )

reticulocytosis ( J:259286 )