Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation
(3 available);
any
Rb1 mutation
(106 available)
Tg(Rbp3-cre)1Brn mutation
(0 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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neoplasm
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• loss of heterozygosity of Trp53 in the neuroendocrine tumors
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• develop pituitary gland and pineal gland tumors
• pinealoblastomas locally invade the brain
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation
(3 available);
any
Rb1 mutation
(106 available)
Tg(Rbp3-cre)1Brn mutation
(0 available)
|
|
|
neoplasm
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• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland
• however, do not develop retinoblastomas or pineal gland tumors
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• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland
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endocrine/exocrine glands
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• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland
• however, do not develop retinoblastomas or pineal gland tumors
|
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• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland
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vision/eye
nervous system
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• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland
• however, do not develop retinoblastomas or pineal gland tumors
|
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• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland
|