Phenotypes associated with this allele
Allelic
Composition |
Tyrp1B-w/Tyrp1+
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Genetic
Background |
involves: 101/Rl * C3H/Rl |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-w mutation
(14 available);
any
Tyrp1 mutation
(162 available)
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pigmentation
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• pigment reduction at base of the hair
(J:13492)
• the hair is almost black except for the extreme base which is light
(J:13492)
• pigment loss is due to premature melanocyte death
(J:18590)
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integument
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• pigment reduction at base of the hair
(J:13492)
• the hair is almost black except for the extreme base which is light
(J:13492)
• pigment loss is due to premature melanocyte death
(J:18590)
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Allelic
Composition |
Tyrp1B-lt/Tyrp1+
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Genetic
Background |
involves: C58 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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pigmentation
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• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes
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integument
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• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes
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Allelic
Composition |
Tyrp1B-lt/Tyrp1+
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Genetic
Background |
Not Specified |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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hearing/vestibular/ear
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• potential is reduced in 30% of mice as mice age
• reduction in potential is correlated with appearance of abundant pigment clumps in the stria vascularis
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pigmentation
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• coat pigment is reduced with age
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integument
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• coat pigment is reduced with age
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pigmentation
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• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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integument
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• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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Allelic
Composition |
a/a
Tyrp1B-lt/Tyrp1+
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Genetic
Background |
Not Specified |
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pigmentation
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• the ventral hairs are substantially less pigmented than those of the dorsum
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• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
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• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes
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integument
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• the ventral hairs are substantially less pigmented than those of the dorsum
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• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
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• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes
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Allelic
Composition |
A/?
Lystbg/Lystbg
Tyrp1+/?
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Genetic
Background |
Not Specified |
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pigmentation
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• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
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• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
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• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
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• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls
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• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults
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vision/eye
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• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults
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limbs/digits/tail
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• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls
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craniofacial
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• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
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hearing/vestibular/ear
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• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
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integument
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• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
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• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
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• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
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• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls
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growth/size/body
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• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
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Analysis Tools