Analysis Tools
cellular
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• in the plasma membrane of the extensor digitorum longus, caveola density is increased while the density of intramembranous particles is decreased
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Allele Symbol Allele Name Allele ID |
Dmdtm1Mok targeted mutation 1, Motoya Katsuki MGI:2429942 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the plasma membrane of the extensor digitorum longus, caveola density is increased while the density of intramembranous particles is decreased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 4 and 4.5 months of age, the diaphragm exhibits an increase in connective tissue
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• at 4 and 4.5 months of age, dissected muscles are whitish and hypertrophic
• several muscles exhibit an increase in size and an increase in connective tissue with necrotic fibers
• muscle degeneration is similar to that observed in other Dmd deficient mice
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• in the plasma membrane of the extensor digitorum longus, caveola density is increased while the density of intramembranous particles is decreased
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Duchenne muscular dystrophy | DOID:11723 |
OMIM:310200 |
J:43164 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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