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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Brca1tm2Mak
targeted mutation 2, Tak W Mak
MGI:2429692
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834729
cn2
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Trp53tm1Brd/Trp53tm1Brd
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834730
cn3
Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834731
cn4
Brca1tm2Mak/Brca1tm2Mak
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834732
cn5
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Tg(TcrLCMV)327Sdz/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834733
cn6
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834734
cn7
Brca1tm2Mak/Brca1tm2Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834735
cn8
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834736
cn9
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53+
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834737
cn10
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53tm1Brd
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834738


Genotype
MGI:3834729
cn1
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced proliferation when stimulated with monoclonal antibody to CD3e
• increased proportion of double negative thymocytes
• absolute number of double negative thymocytes is normal
• less than 10% of number in controls
• less than 10% of number in controls
• 90% reduction in thymocyte number

cellular
• fewer T cells entering S phase
• reduced viability of thymocytes in culture
• reduced survival of T cells when stimulated with monoclonal antibody to CD3e
• increased thymocyte sensitivity of gamma-irradiation
• reduced proliferation when stimulated with monoclonal antibody to CD3e

neoplasm
• only about 12% with tumors
• most tumors are peripheral rather than thymic

hematopoietic system
• reduced proliferation when stimulated with monoclonal antibody to CD3e
• 90% reduction in thymocyte number
• increased proportion of double negative thymocytes
• absolute number of double negative thymocytes is normal
• less than 10% of number in controls
• less than 10% of number in controls

endocrine/exocrine glands
• 90% reduction in thymocyte number




Genotype
MGI:3834730
cn2
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(Lck-cre)548Jxm mutation (2 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• increased incidence
• reduced latency

mortality/aging
• most mice with thymic lymphomas are moribund or die by 3 months of age

cellular
• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

immune system
N
• thymus cellularity restored
• T cell numbers in lymph nodes are improved

neoplasm
• increased incidence
• reduced latency




Genotype
MGI:3834731
cn3
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(BCL2)36Wehi mutation (3 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

immune system
N
• thymus cellularity restored




Genotype
MGI:3834732
cn4
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Tg(Lck-cre)548Jxm/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Cdkn1atm1Tyj mutation (3 available); any Cdkn1a mutation (51 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T cell numbers in lymph nodes are more nearly normal

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:3834733
cn5
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Tg(TcrLCMV)327Sdz/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(Lck-cre)548Jxm mutation (2 available)
Tg(TcrLCMV)327Sdz mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3834734
cn6
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Lck-cre)548Jxm/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Chek2tm1Mak mutation (1 available); any Chek2 mutation (37 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 32% with lymphomas by 180 days of age
• tumors are restricted to the thymus

immune system
N
• complete thymocyte restoration
• T cell numbers in the periphery are restored

cellular
N
• resistant to gamma irradiation
• restoration of normal cell cycle arrest of T cells when stimulated with antibody to CD3e or CD3 and Il2
• increased frequency

neoplasm
• 32% with lymphomas by 180 days of age
• tumors are restricted to the thymus




Genotype
MGI:3834735
cn7
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(Wap-cre)11738Mam mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• only a mild predisposition to mammary cancer (12%)

integument
• only a mild predisposition to mammary cancer (12%)

neoplasm
• only a mild predisposition to mammary cancer (12%)




Genotype
MGI:3834736
cn8
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Chek2tm1Mak mutation (1 available); any Chek2 mutation (37 available)
Tg(Wap-cre)11738Mam mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• about 50% develop acinar adenocarcenomas

integument
• about 50% develop acinar adenocarcenomas

neoplasm
• about 50% develop acinar adenocarcenomas




Genotype
MGI:3834737
cn9
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53+
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(Wap-cre)11738Mam mutation (4 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• about 80% develop acinar adenocarcenomas

endocrine/exocrine glands
• about 80% develop acinar adenocarcenomas

neoplasm
• about 80% develop acinar adenocarcenomas




Genotype
MGI:3834738
cn10
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53tm1Brd
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(Wap-cre)11738Mam mutation (4 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• usually succumb early to other tumors before developing mammary tumors





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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory