All Phenotypes Chl1<tm1Mtg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chl1^tm1Mtg/Chl1^tm1Mtg	B6.129P2-Chl1^tm1Mtg	MGI:3844704
hm2	Chl1^tm1Mtg/Chl1^tm1Mtg	involves: 129P2/OlaHsd * C57BL/6	MGI:2662584
ht3	Chl1^tm1Mtg/Chl1⁺	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3820312
cx4	Chl1^tm1Mtg/Chl1⁺ Cntn6^tm1Kwat/Cntn6⁺	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3820310
cx5	Chl1^tm1Mtg/Chl1^tm1Mtg Tg(Pvalb-EGFP)B20Zjh/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3805898

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

enlarged lateral ventricles ( J:79902 )

• Background Sensitivity: after backcrossing to C57BL/6 for 10 generations, mutants exhibit an enlargement of the lateral ventricles

abnormal hippocampal mossy fiber morphology ( J:79902 )

• mossy fibers invade the CA3 pyramidal cell layer forming a network between the suprapyramidal and infrapyramidal bundles

abnormal olfactory neuron innervation pattern ( J:79902 )

• projection pattern of some sensory olfactory neurons is altered in the olfactory bulb

behavior/neurological

abnormal response to new environment ( J:79902 )

• mutants spend more time (52%) in the central area of the open field test compared to wild-type (36%) and move a shorter total distance, indicating changes in the exploratory behavior or reduced anxiety in novel environment

• mutants show differences in the Morris water maze with respect to the path swimming parallel to the wall and increased swim path tortuosity, absolute spin, and time spent in the center quadrant, indicating altered exploratory behavior, however spatial learning is not impaired

decreased anxiety-related response ( J:79902 )

• in the elevated plus maze, mutants enter the open arm more often, spend less time in the closed arm, and stay longer in the central part of the maze, however, no difference in the light-dark avoidance test is observed

craniofacial

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

respiratory system

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

growth/size/body

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

Allelic Composition	Chl1^tm1Mtg/Chl1^tm1Mtg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chl1^tm1Mtg mutation (0 available); any Chl1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:79902 )

N	• Background Sensitivity: mutants on a mixed 129P2/OlaHsd and C57BL/6 background do not show enlargement of the lateral ventricles until they have been backcrossed to C57BL/6 for 10 generations

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

abnormal hippocampal mossy fiber morphology ( J:79902 )

• mossy fiber organization is altered, with some axons forming small bundles or traveling as individual thin mossy fibers through the CA3 region, forming a network between the suprapyramidal and infrapyramidal bundles

abnormal olfactory neuron innervation pattern ( J:79902 )

• projection pattern of some sensory olfactory neurons is altered in the olfactory bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

respiratory system

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

growth/size/body

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

Allelic Composition	Chl1^tm1Mtg/Chl1⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chl1^tm1Mtg mutation (0 available); any Chl1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex pyramidal cell morphology ( J:130375 )

• mutants exhibit misorientation of apical dendrites of layer V pyramidal neurons in the visual cortex

Allelic Composition	Chl1^tm1Mtg/Chl1⁺ Cntn6^tm1Kwat/Cntn6⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chl1^tm1Mtg mutation (0 available); any Chl1 mutation (56 available)
Cntn6^tm1Kwat mutation (1 available); any Cntn6 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex pyramidal cell morphology ( J:130375 )

• mutants exhibit a more severe misorientation of apical dendrites in layer V pyramidal neurons in the visual cortex than seen in either heterozygous mouse

Allelic Composition	Chl1^tm1Mtg/Chl1^tm1Mtg Tg(Pvalb-EGFP)B20Zjh/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chl1^tm1Mtg mutation (0 available); any Chl1 mutation (56 available)
Tg(Pvalb-EGFP)B20Zjh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain interneuron morphology ( J:136656 )

• stellate axons appear thinner, more wavy, with significantly altered orientation and trajectories compared to controls at P40

• stellate axons display reduced association with Bergmann glial fibers and a reduction of vertically oriented branches

abnormal Purkinje cell innervation ( J:136656 )

• at P44, density of symmetric synapses at Purkinje dendrites is reduced by 60%; density of symmetric synapses at Purkinje dendrites is reduced by 40% at P30

abnormal axon morphology ( J:136656 )

• stellate axons appear thinner, more wavy, with significantly altered orientation and trajectories compared to controls at P40

• stellate axons display reduced association with Bergmann glial (BG) fibers and a reduction of vertically oriented branches, with >30% of stellate axon branches associated with BG fibers; this is apparent at P16 and P20

• basket axons and their innervation of Purkinje cells appears normal

abnormal synaptic bouton morphology ( J:136656 )

• abnormal stellate axons have smaller boutons than wild-type

axon degeneration ( J:136656 )

• in upper molecular layer of the cerebellum in 3 month-old mice, degenerating axon profiles are often observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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