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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cptm1Yos
targeted mutation 1, Kunihiro Yoshida
MGI:2429641
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cptm1Yos/Cptm1Yos C.129P2-Cptm1Yos MGI:3834850
hm2
Cptm1Yos/Cptm1Yos involves: 129P2/OlaHsd * BALB/c MGI:3834849


Genotype
MGI:3834850
hm1
Allelic
Composition
Cptm1Yos/Cptm1Yos
Genetic
Background
C.129P2-Cptm1Yos
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cptm1Yos mutation (0 available); any Cp mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• elevated levels of the lipid peroxidation product acrolein in hippocampal neuron cytoplasm
• ubiquitin levels elevated as well

behavior/neurological
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• reduced activity
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• tendency to stagger

Mouse Models of Human Disease
OMIM ID Ref(s)
Aceruloplasminemia 604290 J:142713




Genotype
MGI:3834849
hm2
Allelic
Composition
Cptm1Yos/Cptm1Yos
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cptm1Yos mutation (0 available); any Cp mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• iron deposits in the liver elevated 3.4 fold
• iron deposits in the cytoplasm of both hepatocytes and Kupffer cells
• in periportal areas and around the central veins

liver/biliary system
• elevated iron in the cytoplasm
• iron deposits in the liver elevated 3.4 fold
• iron deposits in the cytoplasm of both hepatocytes and Kupffer cells
• in periportal areas and around the central veins
• elevated iron in the cytoplasm

hematopoietic system
• elevated iron in the cytoplasm

immune system
• elevated iron in the cytoplasm

cardiovascular system
• elevated iron in the cytoplasm





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory