Mouse Genome Informatics
hm1
    Cptm1Yos/Cptm1Yos
C.129P2-Cptm1Yos
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• elevated levels of the lipid peroxidation product acrolein in hippocampal neuron cytoplasm
• ubiquitin levels elevated as well

behavior/neurological
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• reduced activity
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• tendency to stagger

Mouse Models of Human Disease
OMIM IDRef(s)
Aceruloplasminemia 604290 J:142713


Mouse Genome Informatics
hm2
    Cptm1Yos/Cptm1Yos
involves: 129P2/OlaHsd * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• iron deposits in the liver elevated 3.4 fold
• iron deposits in the cytoplasm of both hepatocytes and Kupffer cells
• in periportal areas and around the central veins

liver/biliary system
• elevated iron in the cytoplasm
• iron deposits in the liver elevated 3.4 fold
• iron deposits in the cytoplasm of both hepatocytes and Kupffer cells
• in periportal areas and around the central veins
• elevated iron in the cytoplasm

hematopoietic system
• elevated iron in the cytoplasm

immune system
• elevated iron in the cytoplasm

cardiovascular system
• elevated iron in the cytoplasm