Mouse Genome Informatics
hm1
     Cptm1Yos/Cptm1Yos
C.129P2-Cptm1Yos
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:142713 )
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• elevated levels of the lipid peroxidation product acrolein in hippocampal neuron cytoplasm
• ubiquitin levels elevated as well

behavior/neurological
abnormal locomotor activation ( J:142713 )
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• reduced activity
abnormal gait ( J:142713 )
• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks
• tendency to stagger

Mouse Models of Human Disease
 OMIM IDRef(s)
Aceruloplasminemia 604290 J:142713


Mouse Genome Informatics
hm2
     Cptm1Yos/Cptm1Yos
involves: 129P2/OlaHsd * BALB/c
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:79916 )
• iron deposits in the liver elevated 3.4 fold
• iron deposits in the cytoplasm of both hepatocytes and Kupffer cells
• in periportal areas and around the central veins

liver/biliary system
abnormal Kupffer cell morphology ( J:79916 )
• elevated iron in the cytoplasm
increased liver iron level ( J:79916 )
• iron deposits in the liver elevated 3.4 fold
• iron deposits in the cytoplasm of both hepatocytes and Kupffer cells
• in periportal areas and around the central veins
abnormal hepatocyte morphology ( J:79916 )
• elevated iron in the cytoplasm

hematopoietic system
abnormal Kupffer cell morphology ( J:79916 )
• elevated iron in the cytoplasm

immune system
abnormal Kupffer cell morphology ( J:79916 )
• elevated iron in the cytoplasm

cardiovascular system
abnormal Kupffer cell morphology ( J:79916 )
• elevated iron in the cytoplasm