All Phenotypes Tg(Hsp70-1-cre)1Arge MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Hsp70-1-cre)1Arge
transgene insertion 1, Argiris Efstratiadis
MGI:2389571

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA	MGI:3805023
cn2	Brca1^tm1Arge/Brca1^tm1Arge Tg(Hsp70-1-cre)1Arge/0	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3805031
cn3	Actb^tm2(Tag)Arge/Actb⁺ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032629
cn4	Actb^{tm1(PyVT)Arge}/Actb⁺ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032631
cn5	Htt^tm4Szi/Htt^tm5Szi Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3664662
cn6	Htt^tm4Szi/Htt^tm4Szi Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3664663
cn7	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3837706
cn8	Hus1^tm1Led/Hus1^tm1Rsw Tg(Hsp70-1-cre)1Arge/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA	MGI:3590177

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (54 available)
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (54 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

Allelic Composition	Brca1^tm1Arge/Brca1^tm1Arge Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

Allelic Composition	Actb^tm2(Tag)Arge/Actb⁺ Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^tm2(Tag)Arge mutation (0 available); any Actb mutation (51 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

endocrine/exocrine glands

enlarged seminal vesicle ( J:87544 )

• enlarged due to pronounced hyperplasia of smooth muscle layers

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

liver/biliary system

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

muscle

abnormal smooth muscle morphology ( J:87544 )

• smooth muscle hyperproliferation in both males and females

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

reproductive system

enlarged seminal vesicle ( J:87544 )

• enlarged due to pronounced hyperplasia of smooth muscle layers

abnormal uterus morphology ( J:87544 )

• development of leiomyosarcomas in the uterus

growth/size/body

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

Allelic Composition	Actb^{tm1(PyVT)Arge}/Actb⁺ Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm1(PyVT)Arge} mutation (0 available); any Actb mutation (51 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:87544 )

• death by E6.5

Allelic Composition	Htt^tm4Szi/Htt^tm5Szi Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm4Szi mutation (0 available); any Htt mutation (179 available)
Htt^tm5Szi mutation (0 available); any Htt mutation (179 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type; embryonic portion of conceptus is small and stubby with no obvious head folds and somites are absent

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

embryo

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

abnormal embryonic tissue morphology ( J:111323 )

• embryonic portion of conceptus is small and stubby with no obvious head folds

absent somites ( J:111323 )

• at E8.5

growth/size/body

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

Allelic Composition	Htt^tm4Szi/Htt^tm4Szi Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm4Szi mutation (0 available); any Htt mutation (179 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type; embryonic portion of conceptus is small and stubby with no obvious head folds and somites are absent

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

embryo

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

abnormal embryonic tissue morphology ( J:111323 )

• embryonic portion of conceptus is small and stubby with no obvious head folds

absent somites ( J:111323 )

• at E8.5

growth/size/body

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:146290 )

Allelic Composition	Hus1^tm1Led/Hus1^tm1Rsw Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hus1^tm1Led mutation (0 available); any Hus1 mutation (20 available)
Hus1^tm1Rsw mutation (0 available); any Hus1 mutation (20 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:99339 )

• fewer than expected mutants are found and those that do survive have little or no Cre-mediated recombination in most tissues with the exception of the lung and mammary gland where moderate levels of recombination are seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23