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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adgrv1frings
frings
MGI:2389570
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adgrv1frings/Adgrv1frings BUB/BnJ MGI:3581702
hm2
Adgrv1frings/Adgrv1frings RB/1 MGI:2389583
cx3
Adgrv1frings/Adgrv1frings
Cdh23ahl/Cdh23ahl
involves: BUB/BnJ * CAST/EiJ MGI:3581700
cx4
Adgrv1frings/Adgrv1frings
Cdh23ahl/Cdh23ahl
involves: BUB/BnJ * MOLD/RkJ MGI:3581701
cx5
Cdh23ahl/Cdh23ahl
Adgrv1frings/Adgrv1frings
involves: BUB/BnJ * RB/1 MGI:3701599


Genotype
MGI:3581702
hm1
Allelic
Composition
Adgrv1frings/Adgrv1frings
Genetic
Background
BUB/BnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrv1frings mutation (1 available); any Adgrv1 mutation (188 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• the stereocilia bundle of outer cells along the length of the neuroepithelium is largely immature and underdeveloped at postnatal day 14
• lateral and apical aspects of the bundle appear rounded and deformed
• stereocilia ae disconnected and detached, found outside of the unit, and are bent
• pronounced in the basal turn at 15 weeks of age
• exhibit ABR threshold about 40 dB higher than the normal thresholds of control at 15 weeks of age
• rate of threshold improvement in mutant mice was approximately ten times slower than in normal mice
• exhibit ABR threshold about 40 dB higher than the normal thresholds of control at 15 weeks of age, and this hearing loss progresses to deafness by 20 weeks of age
• progressive hearing loss
• early onset hearing loss starting before 6 months of age
• deafness by 20 weeks of age

behavior/neurological
• Background Sensitivity: BUNB/BnJ mice show audiogenic seizure only when tested at young ages (<25 days od age), whereas original RB/1 mice homozygous for this allele retain seizure sensitivity well into adulthood

nervous system
• Background Sensitivity: BUNB/BnJ mice show audiogenic seizure only when tested at young ages (<25 days od age), whereas original RB/1 mice homozygous for this allele retain seizure sensitivity well into adulthood
• the stereocilia bundle of outer cells along the length of the neuroepithelium is largely immature and underdeveloped at postnatal day 14
• lateral and apical aspects of the bundle appear rounded and deformed
• stereocilia ae disconnected and detached, found outside of the unit, and are bent
• pronounced in the basal turn at 15 weeks of age
• pronounced in the basal turn at 15 weeks of age




Genotype
MGI:2389583
hm2
Allelic
Composition
Adgrv1frings/Adgrv1frings
Genetic
Background
RB/1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrv1frings mutation (1 available); any Adgrv1 mutation (188 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• characterized by wild running, loss of righting reflex, tonic flexion, and tonic extension in response to sound stimulation

nervous system
• characterized by wild running, loss of righting reflex, tonic flexion, and tonic extension in response to sound stimulation




Genotype
MGI:3581700
cx3
Allelic
Composition
Adgrv1frings/Adgrv1frings
Cdh23ahl/Cdh23ahl
Genetic
Background
involves: BUB/BnJ * CAST/EiJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrv1frings mutation (1 available); any Adgrv1 mutation (188 available)
Cdh23ahl mutation (55 available); any Cdh23 mutation (196 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• severe hearing loss by 5 months of age




Genotype
MGI:3581701
cx4
Allelic
Composition
Adgrv1frings/Adgrv1frings
Cdh23ahl/Cdh23ahl
Genetic
Background
involves: BUB/BnJ * MOLD/RkJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrv1frings mutation (1 available); any Adgrv1 mutation (188 available)
Cdh23ahl mutation (55 available); any Cdh23 mutation (196 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• severe hearing loss by 5 months of age




Genotype
MGI:3701599
cx5
Allelic
Composition
Cdh23ahl/Cdh23ahl
Adgrv1frings/Adgrv1frings
Genetic
Background
involves: BUB/BnJ * RB/1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrv1frings mutation (1 available); any Adgrv1 mutation (188 available)
Cdh23ahl mutation (55 available); any Cdh23 mutation (196 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• exhibit the highest ABR threshold compared to single homozygous mice Gpr98frings/Gpr98frings Cdh23ahl/Cdh23+ and Gpr98frings/Gpr98+ Cdh23ahl/Cdh23ahl
• already near deaf by 5 months of age





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory