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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad2tm2Kato
targeted mutation 2, Mitsuyasu Kato
MGI:2389479
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad2tm2Kato/Smad2tm2Kato involves: 129S4/SvJae * C57BL/6J MGI:3790615
cx2
 		Apctm1Mmt/Apc+
Smad2tm2Kato/Smad2+ 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J MGI:3790616


Genotype
MGI:3790615
hm1
Allelic
Composition		 Smad2tm2Kato/Smad2tm2Kato
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm2Kato mutation (0 available); any Smad2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal developmental patterning ( J:79668 )
• phenotype is similar to that of Smad2tm1Enl homozygotes; however no data are presented




Genotype
MGI:3790616
cx2
Allelic
Composition		 Apctm1Mmt/Apc+
Smad2tm2Kato/Smad2+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Mmt mutation (0 available); any Apc mutation (154 available)
Smad2tm2Kato mutation (0 available); any Smad2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:79668 )
• a small number of mice die suddenly, before thirty weeks of age, as result of lethal intestinal obstruction by large tumorous polyps

neoplasm
increased intestinal adenoma incidence ( J:79668 )
• numerous intestinal tumors develop in homozygotes: compound mutants have more intestinal tumors >4 mm in diameter than Apctm1Mmt heterozygotes
• frequently one or two tumors >6 mm in diameter develop
• 10-15% of intestinal polyps exhibit stromal and vascular invasion
• tubular adenomas vary in size and shape, and solid colonies of poorly differentiated carcinoma cells are sometimes observed
• nuclei display more hyperchromaticity than those in tumors in Apc single heterozygotes; nuclear atypia in tumors is enhanced indicating increased malignancy

digestive/alimentary system
increased intestinal adenoma incidence ( J:79668 )
• numerous intestinal tumors develop in homozygotes: compound mutants have more intestinal tumors >4 mm in diameter than Apctm1Mmt heterozygotes
• frequently one or two tumors >6 mm in diameter develop
• 10-15% of intestinal polyps exhibit stromal and vascular invasion
• tubular adenomas vary in size and shape, and solid colonies of poorly differentiated carcinoma cells are sometimes observed
• nuclei display more hyperchromaticity than those in tumors in Apc single heterozygotes; nuclear atypia in tumors is enhanced indicating increased malignancy




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory