Analysis Tools
immune system
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• the mixed lymphocyte response is reduced 3- to 4-fold
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• cultured B cells exhibited greatly reduced proliferation upon stimulation with LPS, anti-CD40, anti-IgM, and Il4
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• in vitro, fewer CD4+ cells enter the cell cycle and those that do undergo fewer rounds of division
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• severe impairment of anti-NP IgG production
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• less interferon-gamma is secreted in a mixed lymphocyte response
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• mice retain MHC-mismatched allografts for 17 days compared to 1 week in wild-type mice
• MHC-mismatched allograft retention is prolonged to 40 days with 50% of mice retaining allografts for greater than 100 days with the use of cyclosporine A compared to an enhancement of only a few days in wild-type mice
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hematopoietic system
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• the mixed lymphocyte response is reduced 3- to 4-fold
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• cultured B cells exhibited greatly reduced proliferation upon stimulation with LPS, anti-CD40, anti-IgM, and Il4
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• in vitro, fewer CD4+ cells enter the cell cycle and those that do undergo fewer rounds of division
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• severe impairment of anti-NP IgG production
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cellular
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• cultured B cells exhibited greatly reduced proliferation upon stimulation with LPS, anti-CD40, anti-IgM, and Il4
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• in vitro, fewer CD4+ cells enter the cell cycle and those that do undergo fewer rounds of division
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