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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfsf4tm1Sug
targeted mutation 1, Kazuo Sugamura
MGI:2388724
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfsf4tm1Sug/Tnfsf4tm1Sug B6.129S4-Tnfsf4tm1Sug MGI:2651597


Genotype
MGI:2651597
hm1
Allelic
Composition
Tnfsf4tm1Sug/Tnfsf4tm1Sug
Genetic
Background
B6.129S4-Tnfsf4tm1Sug
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf4tm1Sug mutation (1 available); any Tnfsf4 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced hapten-specific T cell proliferative response

immune system
• reduced hapten-specific T cell proliferative response
• decreased ear swelling 24 hours following challenge with 4-dinitrofluorobenzene (DNFB), 6-trinitrochlorobenzene (TNCB), and FITC compared to wild-type
• reduced hapten-specific T cell proliferative response; however, migratory responses are normal

hematopoietic system
• reduced hapten-specific T cell proliferative response





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory