Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Mok mutation
(2 available);
any
Trp53 mutation
(232 available)
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Allelic Composition |
Trp53tm2Mok/Trp53+
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Genetic Background |
involves: 129S/SvEv * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Mok mutation
(2 available);
any
Trp53 mutation
(232 available)
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cellular
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• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7tm1Hmas mutation
(0 available);
any
Cdc7 mutation
(34 available)
Trp53tm2Mok mutation
(2 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• mutant embryos die around E8.5
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embryo
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation
(0 available);
any
Hipk1 mutation
(61 available)
Hipk2tm1Hko mutation
(0 available);
any
Hipk2 mutation
(53 available)
Trp53tm2Mok mutation
(2 available);
any
Trp53 mutation
(232 available)
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nervous system
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• four triple mutants were found to be exencephalic, whereas none were found to be wild-type for Trp53
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