About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm2Mok
targeted mutation 2, Motoya Katsuki
MGI:2388703
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp53tm2Mok/Trp53tm2Mok involves: 129S/SvEv * C57BL/6 MGI:4438456
ht2
Trp53tm2Mok/Trp53+ involves: 129S/SvEv * C57BL/6 MGI:3625002
cx3
Cdc7tm1Hmas/Cdc7tm1Hmas
Trp53tm2Mok/Trp53tm2Mok
involves: 129S/Sv * C57BL/6 MGI:2662267
cx4
Hipk1tm1Hko/Hipk1tm1Hko
Hipk2tm1Hko/Hipk2tm1Hko
Trp53tm2Mok/Trp53+
involves: 129S/SvEv * C57BL/6 MGI:3625003


Genotype
MGI:4438456
hm1
Allelic
Composition
Trp53tm2Mok/Trp53tm2Mok
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Mok mutation (2 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm




Genotype
MGI:3625002
ht2
Allelic
Composition
Trp53tm2Mok/Trp53+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Mok mutation (2 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type




Genotype
MGI:2662267
cx3
Allelic
Composition
Cdc7tm1Hmas/Cdc7tm1Hmas
Trp53tm2Mok/Trp53tm2Mok
Genetic
Background
involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7tm1Hmas mutation (0 available); any Cdc7 mutation (34 available)
Trp53tm2Mok mutation (2 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo

growth/size/body




Genotype
MGI:3625003
cx4
Allelic
Composition
Hipk1tm1Hko/Hipk1tm1Hko
Hipk2tm1Hko/Hipk2tm1Hko
Trp53tm2Mok/Trp53+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation (0 available); any Hipk1 mutation (61 available)
Hipk2tm1Hko mutation (0 available); any Hipk2 mutation (53 available)
Trp53tm2Mok mutation (2 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• four triple mutants were found to be exencephalic, whereas none were found to be wild-type for Trp53





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory