Phenotypes associated with this allele

• Allele Symbol: Nqo1^tm1Akj
• Allele Name: targeted mutation 1, Anil K Jaiswal
• Allele ID: MGI:2388490
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nqo1^tm1Akj/Nqo1^tm1Akj	involves: C57BL/6	MGI:3806668
hm2	Nqo1^tm1Akj/Nqo1^tm1Akj	Not Specified	MGI:3522049

Genotype
MGI:3806668

hm1

• Allelic Composition: Nqo1^tm1Akj/Nqo1^tm1Akj
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:120478 )

• total body weight is significantly lower than normal at all three ages (24, 48, and 72 weeks) studied

adipose tissue

decreased abdominal adipose tissue amount ( J:120478 )

• homozygotes fail to accumulate abdominal adipose tissue with increasing age

• at 24, 48, and 72 weeks of age, homozygotes show a 20%, 38% and a striking 326% reduction in adbominal adipose tissue relative to wild-type, respectively

homeostasis/metabolism

decreased circulating glucose level ( J:120478 )

• at 24, 48, and 72 weeks of age, serum glucose levels are decreased by 11%, 35%, and 36%, respectively, relative to wild-type values

increased circulating glucagon level ( J:120478 )

abnormal gluconeogenesis ( J:120478 )

insulin resistance ( J:120478 )

increased triglyceride level ( J:120478 )

increased circulating triglyceride level ( J:120478 )

abnormal nucleotide metabolism ( J:120478 )

cellular

abnormal redox activity ( J:120478 )

Genotype
MGI:3522049

hm2

• Allelic Composition: Nqo1^tm1Akj/Nqo1^tm1Akj
• Genetic Background: Not Specified

neoplasm

increased skin tumor incidence ( J:66196 )

• increased susceptibility to benzopyrene

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:46669 )

• increased susceptiblity to vitamin K3 toxicity (menadione)

integument

increased skin tumor incidence ( J:66196 )

• increased susceptibility to benzopyrene