Analysis Tools
behavior/neurological
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• mutants tend to step down at a lower latency in a step-down passive avoidance test than wild-types; mutants did not increase latency to step down compared to conditioning trials as do wild-type mice
• when placed inside the Plexiglass cylinder onto the platform in the avoidance test, significantly more mutant mice show an active (jumping) response compared to wild-type and a passive (remaining on platform for 60 seconds) response less frequently
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• in an elevated-plus maze test, mutant mice show differences in numerous behavior parameters showing a lower anxiety profile; mutants entered the open arms more often, spent less time in the closed arms and showed less stretch attend posture from the protected area towards the open arms, while spending more time doing unprotected head dipping compared to wild-type
• in open-field and elevated-plus maze in a second set of experiments, mutants show less stretch attend posture and rear more frequently at the new object than wild-type
• 75% of mutant mice that entered at least once into the open arms reached to edge of the open arm furthest away from the center compared to 29% of wild-type
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• mutant mice contact and enter into a new object more quickly than wild-type; mutants show less stretch attend posture and rear more frequently at the new object than wild-type
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• 10-16 week old mutants show lower strength in the grip test compared to wild-type mice; knockout mice fell at lower latencies than wild-type
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• from day 3 to day 7 of analysis of circadian activity, mutants were less active during the dark phase; duing the first 4 hours of the dark phase from day 3 to day 9, mutants show lower activity than wild-type indicating an impairment in resynchronizing circadian rhythm to a daylight reversal
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