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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fxr2tm1Cgr
targeted mutation 1, Ben Oostra
MGI:2388128
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fxr2tm1Cgr/Fxr2tm1Cgr involves: 129S7/SvEvBrd * C57BL/6J * FVB MGI:2672023


Genotype
MGI:2672023
hm1
Allelic
Composition
Fxr2tm1Cgr/Fxr2tm1Cgr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fxr2tm1Cgr mutation (1 available); any Fxr2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• swim distance and time to locate hidden plateforms are significantly greater in a Morris water maze test
• use a spatially biased search strategy however
• impaired context related fear responses
• performance on a rotarod significantly poorer than controls although improvement with testing is comparable
• more active in open field tests than controls
• travel greater distances, spend more time in motion, travel faster
• less sensitive to painful stimuli in a hot plate test

nervous system
• decreased prepulse inhibition although startle response is normal

reproductive system
N
• no abnormal reproductive system phenotypes detected





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory