All Phenotypes Cx3cl1<tm1Lira> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cx3cl1^tm1Lira
targeted mutation 1, Sergio A Lira
MGI:2388041

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	involves: 129S/SvEv * C57BL/6	MGI:2447466
hm2	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	involves: C57BL/6	MGI:4834193
hm3	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	Not Specified	MGI:4833987
cx4	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc	MGI:4833678

Allelic Composition	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cl1^tm1Lira mutation (0 available); any Cx3cl1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:68831 )

N	• mice do not exhibit overt behavioral abnormalities

immune system

immune system phenotype ( J:68831 )

N	• the lymph node cellular composition does not differ significantly from that of control mice • the responses of mutant mice to a variety of inflammatory stimuli, including thioglycolate, L. monocytogenes, KLH and DSS, are indistinguishable from those of control mice

nervous system

nervous system phenotype ( J:68831 )

N	• histological analysis of their brains and many other tissues did not reveal any gross changes compared to controls

hematopoietic system

hematopoietic system phenotype ( J:68831 )

N	• mice have normal hematological profiles, including red blood cell number and hematocrit, except for a decrease in the number of blood leukocytes expressing the cell surface marker F4/80

Allelic Composition	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cl1^tm1Lira mutation (0 available); any Cx3cl1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased monocyte cell number ( J:145036 )

• Gr1^low monocytes are reduced compared to in wild-type mice

hematopoietic system

decreased monocyte cell number ( J:145036 )

• Gr1^low monocytes are reduced compared to in wild-type mice

Allelic Composition	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cl1^tm1Lira mutation (0 available); any Cx3cl1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:110266 )

• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neuron loss compared with similarly treated wild-type mice

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:110266 )

• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neuron loss compared with similarly treated wild-type mice

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:110266 )

• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neuron loss compared with similarly treated wild-type mice

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
Genetic Background	B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
Ccr2^tm1Ifc mutation (1 available); any Ccr2 mutation (40 available)
Cx3cl1^tm1Lira mutation (0 available); any Cx3cl1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:153310 )

• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoe^tm1Unc homozygotes and Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

hematopoietic system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

immune system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23