About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Htttm2Msl
targeted mutation 2, Michael S Levine
MGI:2388032
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Htttm2Msl/Htttm2Msl involves: 129S1/Sv * C57BL/6J MGI:3698855


Genotype
MGI:3698855
hm1
Allelic
Composition
Htttm2Msl/Htttm2Msl
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm2Msl mutation (0 available); any Htt mutation (179 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• nuclear microaggregates of mutant protein in striatal neurons are rare at 4 months of age but become widely distributed at 6 months of age and nuclear inclusions do not appear until 18 months of age; microaggregates are predominately found in the striosomal compartment
• total volume of the striatum is significantly reduced in 18 and 26-month old mutants, however show normal numbers of medium spiny neurons which results in increased density of neurons in the striatum
• intracellular recordings show that resting membrane potentials of striatal neurons are significantly more depolarized than in controls
• striatal and cortical neurons display more rapid and increased swelling to N-methyl-D-aspartate (NMDA) than controls, but not to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) or kainate (KA), indicating increased sensitivity to NMDA

behavior/neurological
• exhibit increased rearing at night at 2 months of age but not at later time points
• the initial increase in rearing is followed by decreased locomotion at 4 and 6 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:76018 , J:79137





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory