• mutants die prior to P60

• mutants exhibit tremor starting at 2 weeks of age, followed later by seizures

• mutants develop seizures following tremors

• mutants develop seizures following tremors

• mutants exhibit an increase in the number of apoptotic oligodendrocytes by P20

• oligodendrocytes show swelling of the Golgi apparatus and numerous autophagic vacuoles by P20

• markedly thinner myelin sheath

• mutants exhibit marked dymyelination by P20

• mutants exhibit an increase in the number of apoptotic oligodendrocytes by P20

• die at approximately 2 months of age

• apparent by 2 weeks of age and progressive severity with age

• apparent by 2 weeks of age and progressive severity with age

• apparent by 2 weeks of age and progressive severity with age

• apparent by 2 weeks of age and progressive severity with age

• widespresd astrocytosis in white matter areas of hypomylelinated structures

• increased number of processes

• progressive with age

• more pronounced in forebrain and optic nerves

• less severe in the brainstem and spinal cord

• within the spinal cord, hypomyelination was more severe in the dorsal columns than in the ventral columns

• at 15-18 months of age, mutants develop ataxia

• at 15-18 months of age, mutants begin to lose weight

• slightly thinner myelin sheath

• mice show demyelination starting from 15-18 months of age

• older mice exhibit axonal degeneration preferentially affecting smaller diameter fibers

• at 15-18 months of age, mutants develop kyphosis