Analysis Tools
immune system
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• following immunization, fewer peanut agglutinin positive (PNA+) clusters are present and very few IgD- areas typical of germinal centers are identified
• B cell follicle disruption is not as severe as in Ltb null mice
• however, some follicular dendritic cells are present and immune complex binding is observed
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• follicular dendritic cell (FDC) networks are reduced to 15% to 20% of the number found in wild-type mice
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• following exposure to sheep red blood cells (SRBC) mice fail to develop normal specific IgG responses
• memory IgG responses are reduced compared to wild-type but not as much as in Ltb null mice
• affinity maturation is only slightly reduced
• however, unlike Ltb null mice IgM levels are normal
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hematopoietic system
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• following immunization, fewer peanut agglutinin positive (PNA+) clusters are present and very few IgD- areas typical of germinal centers are identified
• B cell follicle disruption is not as severe as in Ltb null mice
• however, some follicular dendritic cells are present and immune complex binding is observed
|
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• follicular dendritic cell (FDC) networks are reduced to 15% to 20% of the number found in wild-type mice
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