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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adipoqtm1Chan
targeted mutation 1, Lawrence Chan
MGI:2388007
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adipoqtm1Chan/Adipoqtm1Chan B6.129-Adipoqtm1Chan MGI:3841199
hm2
Adipoqtm1Chan/Adipoqtm1Chan involves: 129S1/Sv * 129X1/SvJ MGI:3841225
hm3
Adipoqtm1Chan/Adipoqtm1Chan involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3841221
ht4
Adipoqtm1Chan/Adipoq+ B6.129-Adipoqtm1Chan MGI:3841211
cx5
Adipoqtm1Chan/Adipoq+
Tg(MMTV-PyVT)634Mul/0
B6.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul MGI:3841378
cx6
Adipoqtm1Chan/Adipoqtm1Chan
Tg(MMTV-PyVT)634Mul/0
either: B6.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul or FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul MGI:3841377
cx7
Adipoqtm1Chan/Adipoq+
Tg(MMTV-PyVT)634Mul/0
FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul MGI:3841380


Genotype
MGI:3841199
hm1
Allelic
Composition
Adipoqtm1Chan/Adipoqtm1Chan
Genetic
Background
B6.129-Adipoqtm1Chan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Chan mutation (1 available); any Adipoq mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal glucose homeostasis and response to a high fat diet
• beta oxidization is decreased 47% in muscle cells and 30% in hepatocytes compared to in wild-type mice
• nitric oxide production is decreased 40% compared to in wild-type mice
• however, treatment with human recombinant adiponectin restores nitric oxide levels to near normal
• adiponectin is virtually undetectable in the plasma unlike in wild-type mice

cellular
• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to heterozygous and wild-type endothelium
• beta oxidization is decreased 47% in muscle cells and 30% in hepatocytes compared to in wild-type mice

immune system
• mice exhibit a 2-fold increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice
• however, total leukocyte counts are normal
• leukocyte rolling velocity is decreased compared to in heterozygous and wild type mice
• leukocyte adhesion to vascular endothelium is increased 5-fold compared in wild-type cells
• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

cardiovascular system
• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to heterozygous and wild-type endothelium

hematopoietic system
• mice exhibit a 2-fold increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice
• however, total leukocyte counts are normal
• leukocyte rolling velocity is decreased compared to in heterozygous and wild type mice
• leukocyte adhesion to vascular endothelium is increased 5-fold compared in wild-type cells
• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin




Genotype
MGI:3841225
hm2
Allelic
Composition
Adipoqtm1Chan/Adipoqtm1Chan
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Chan mutation (1 available); any Adipoq mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• after 22 weeks

homeostasis/metabolism
• beta-oxidization in skeletal muscles is increased compared to in wild-type mice

muscle
• in the tibialis, IIB muscle fiber area is increased compared to in wild-type muscle




Genotype
MGI:3841221
hm3
Allelic
Composition
Adipoqtm1Chan/Adipoqtm1Chan
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Chan mutation (1 available); any Adipoq mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit a 2-fold increase in urine albumin levels compared to in wild-type mice between 1 and 3 months that increased further at 4 months of age
• within 2 months, stereptozotocin-induced diabetic mice exhibit a greater increase in urine albumin levels than in similarly treated wild-type mice that progressively increases at 4 months after diabetes induction
• however, treatment with adiponectin restores normoalbuminuria

cellular
• mice exhibit an increase in urine hydrogen peroxide levels compared to in wild-type mice
• stereptozotocin-induced diabetic mice exhibit a greater increase in urine hydrogen peroxide levels than in similarly treated wild-type mice
• however, urine hydrogen peroxide levels are normalize by treatment with adiponectin

homeostasis/metabolism
• mice exhibit a 2-fold increase in urine albumin levels compared to in wild-type mice between 1 and 3 months that increased further at 4 months of age
• within 2 months, stereptozotocin-induced diabetic mice exhibit a greater increase in urine albumin levels than in similarly treated wild-type mice that progressively increases at 4 months after diabetes induction
• however, treatment with adiponectin restores normoalbuminuria




Genotype
MGI:3841211
ht4
Allelic
Composition
Adipoqtm1Chan/Adipoq+
Genetic
Background
B6.129-Adipoqtm1Chan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Chan mutation (1 available); any Adipoq mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes
• however, total leukocyte counts are normal
• leukocyte rolling velocity is decreased compared to in wild type mice
• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells
• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

cellular
• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

cardiovascular system
• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

homeostasis/metabolism
• 58% reduction in total plasma adiponectin levels compared with wild-type mice

hematopoietic system
• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes
• however, total leukocyte counts are normal
• leukocyte rolling velocity is decreased compared to in wild type mice
• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells
• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin




Genotype
MGI:3841378
cx5
Allelic
Composition
Adipoqtm1Chan/Adipoq+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
B6.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Chan mutation (1 available); any Adipoq mutation (30 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Increased metastatic capacity of tumor cells from Adipoqtm1Chan/Adipoq+ Tg(MMTV-PyVT)634Mul/0 mice

growth/size/body

neoplasm
• mice develop tumors with a basal-like subtype
• mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 114 days in males compared to 73 days and 137 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively
• tumor cells implanted into nude mice exhibit increased proliferation and are more aggressive than tumor cells isolated from Tg(MMTV-PyVT)634Mul mice
• tumor cells from male mice exhibit increased metastatic capacity in nude mice compared to tumor cells from Tg(MMTV-PyVT)634Mul mice
• proliferation of tumor-derived cells is more sensitive to adiponectin-mediated inhibition of cell proliferation than tumor cells from Tg(MMTV-PyVT)634Mul mice
• total wet weight of tumors is 2-fold heavier than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
• mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 114 days in males compared to 73 days and 137 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively
• mice develop tumors with a basal-like subtype

respiratory system

integument
• mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 114 days in males compared to 73 days and 137 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively
• mice develop tumors with a basal-like subtype

homeostasis/metabolism




Genotype
MGI:3841377
cx6
Allelic
Composition
Adipoqtm1Chan/Adipoqtm1Chan
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
either: B6.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul or FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Chan mutation (1 available); any Adipoq mutation (30 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3841380
cx7
Allelic
Composition
Adipoqtm1Chan/Adipoq+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Chan mutation (1 available); any Adipoq mutation (30 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

A basal-like subtype of mammary tumors in Adipoqtm1Chan/Adipoq+ Tg(MMTV-PyVT)634Mul/0 mice

growth/size/body

neoplasm
• mice develop mammary gland tumors with a median age of tumor latency of 58 days in females and 115 days in males compared to 66 days and 133.5 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively
• mice develop tumors with a basal-like subtype
• tumor cells implanted into nude mice exhibit increased proliferation and are more aggressive than tumor cells isolated from Tg(MMTV-PyVT)634Mul mice
• tumor cells from male mice exhibit increased metastatic capacity in nude mice compared to tumor cells from Tg(MMTV-PyVT)634Mul mice
• proliferation of tumor-derived cells is more sensitive to adiponectin-mediated inhibition of cell proliferation than tumor cells from Tg(MMTV-PyVT)634Mul mice
• total wet weight of tumors is 2-fold heavier than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
• mice develop mammary gland tumors with a median age of tumor latency of 58 days in females and 115 days in males compared to 66 days and 133.5 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively
• mice develop tumors with a basal-like subtype

respiratory system

integument
• mice develop mammary gland tumors with a median age of tumor latency of 58 days in females and 115 days in males compared to 66 days and 133.5 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively
• mice develop tumors with a basal-like subtype

homeostasis/metabolism





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory