All Phenotypes Nrcam<tm1Gmt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nrcam^tm1Gmt
targeted mutation 1, Martin Grumet
MGI:2387976

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrcam^tm1Gmt/Nrcam^tm1Gmt	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster)	MGI:2388065
hm2	Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129S6/SvEvTac	MGI:3805891
hm3	Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129S6/SvEvTac * ICR	MGI:4840023
hm4	Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129S6/SvEvTac * Swiss Webster	MGI:4461155
cx5	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129P2/OlaHsd * 129S6/SvEvTac * ICR	MGI:4840024
cx6	Cntnap1^tm1Pele/Cntnap1^tm1Pele Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129P2/OlaHsd * ICR	MGI:4840027
cx7	L1cam^tm1Sor/L1cam⁺ Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster	MGI:3806025
cx8	L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster	MGI:3806032
cx9	L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster	MGI:3806030

Allelic Composition	Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lobes IV and V of the cerebellum are smaller in Nrcam^tm1Gmt/Nrcam^tm1Gmt mice

nervous system

small cerebellum ( J:71828 )

• reduced size of lobes IV and V; these lobes contained 11% less gray matter than control littermates; lobes I, II and X are also slightly reduced in size

abnormal neurite morphology ( J:71828 )

• isolated cerebellar cells fail to extend neurites in response to contactin, however neurites still extend in response to RPTPbeta

Allelic Composition	Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:136656 )

N	• Purkinje dendrites appear normal

Allelic Composition	Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129S6/SvEvTac * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:166099 )

• sodium ion channels are absent from heminodes unlike in wild-type mice

• heminodes fail to form unlike in wild-type mice

• however, nodes form normally

Allelic Composition	Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129S6/SvEvTac * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:153165 )

• males and females display a longer latency to reach the escape platform in the reversal phase

abnormal motor learning ( J:153165 )

• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials

abnormal spatial learning ( J:153165 )

• females but not males display a longer latency to find a hidden platform

abnormal locomotor activation ( J:153165 )

• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females

decreased vertical activity ( J:153165 )

• decrease in rearing frequency in an open field in females

abnormal social investigation ( J:153165 )

• males fail to show a preference for a stranger mouse over an empty cage

nervous system

decreased prepulse inhibition ( J:153165 )

• small but significant decrease in males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:153165

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:166099 )

• sodium ion channels are absent from heminodes unlike in wild-type mice

Allelic Composition	Cntnap1^tm1Pele/Cntnap1^tm1Pele Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129P2/OlaHsd * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntnap1^tm1Pele mutation (0 available); any Cntnap1 mutation (56 available)
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:166099 )

• at P8

nervous system

abnormal axon morphology ( J:166099 )

• nodes and heminodes fail to form unlike in wild-type mice

• nodal length is increased compared to in wild-type mice

decreased nerve conduction velocity ( J:166099 )

• at P7

behavior/neurological

ataxia ( J:166099 )

• strong congenital at P4

paralysis ( J:166099 )

Allelic Composition	L1cam^tm1Sor/L1cam⁺ Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1cam^tm1Sor mutation (2 available); any L1cam mutation (12 available)
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:71828 )

• increase in rate of postnatal death, especially during the first 1-2 weeks after birth

Allelic Composition	L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cerebellar abnormalities in L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam^tm1Gmt mice

mortality/aging

postnatal lethality ( J:71828 )

• do not detect any mutants at P8

growth/size/body

decreased body weight ( J:71828 )

• body weights of pups are 40-70% of control littermates at P3-P6

nervous system

abnormal cerebellum development ( J:71828 )

• cerebellar dysgenesis

• cerebellar fissures are less developed

• thickness of the inner granule layer is reduced by 40-50%

abnormal cerebellar foliation ( J:71828 )

• marker analysis indicates defects in foliation

abnormal cerebellum external granule cell layer morphology ( J:71828 )

• thickness of the external granule layer is reduced by 10-30%

abnormal cerebellar cortex morphology ( J:71828 )

• cerebellar lobes are less developed

abnormal cerebellar granule layer morphology ( J:71828 )

• marker analysis indicates possible defects in granule cells during cerebellar development

• thickness of the inner granule layer is reduced by 40-50%

• thickness of the external granule layer is reduced by 10-30%

small cerebellum ( J:71828 )

Allelic Composition	L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:71828 )

• increase in rate of postnatal death, especially during the first 1-2 weeks after birth

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