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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nrcamtm1Gmt
targeted mutation 1, Martin Grumet
MGI:2387976
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nrcamtm1Gmt/Nrcamtm1Gmt either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster) MGI:2388065
hm2
Nrcamtm1Gmt/Nrcamtm1Gmt involves: 129S6/SvEvTac MGI:3805891
hm3
Nrcamtm1Gmt/Nrcamtm1Gmt involves: 129S6/SvEvTac * ICR MGI:4840023
hm4
Nrcamtm1Gmt/Nrcamtm1Gmt involves: 129S6/SvEvTac * Swiss Webster MGI:4461155
cx5
Nfasctm1.1Brp/Nfasctm1.1Brp
Nrcamtm1Gmt/Nrcamtm1Gmt
involves: 129P2/OlaHsd * 129S6/SvEvTac * ICR MGI:4840024
cx6
Cntnap1tm1Pele/Cntnap1tm1Pele
Nrcamtm1Gmt/Nrcamtm1Gmt
involves: 129P2/OlaHsd * ICR MGI:4840027
cx7
L1camtm1Sor/L1cam+
Nrcamtm1Gmt/Nrcamtm1Gmt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster MGI:3806025
cx8
L1camtm1Sor/Y
Nrcamtm1Gmt/Nrcam+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster MGI:3806030
cx9
L1camtm1Sor/Y
Nrcamtm1Gmt/Nrcamtm1Gmt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster MGI:3806032


Genotype
MGI:2388065
hm1
Allelic
Composition
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lobes IV and V of the cerebellum are smaller in Nrcamtm1Gmt/Nrcamtm1Gmt mice

nervous system
• reduced size of lobes IV and V; these lobes contained 11% less gray matter than control littermates; lobes I, II and X are also slightly reduced in size (J:71828)
• reduced size of lobes IV and V; these lobes contained 11% less gray matter than control littermates; lobes I, II and X are also slightly reduced in size (J:71828)
• isolated cerebellar cells fail to extend neurites in response to contactin, however neurites still extend in response to RPTPbeta (J:71828)
• isolated cerebellar cells fail to extend neurites in response to contactin, however neurites still extend in response to RPTPbeta (J:71828)




Genotype
MGI:3805891
hm2
Allelic
Composition
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• Purkinje dendrites appear normal (J:136656)
• Purkinje dendrites appear normal (J:136656)




Genotype
MGI:4840023
hm3
Allelic
Composition
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129S6/SvEvTac * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• sodium ion channels are absent from heminodes unlike in wild-type mice (J:166099)
• heminodes fail to form unlike in wild-type mice (J:166099)
• however, nodes form normally (J:166099)
• sodium ion channels are absent from heminodes unlike in wild-type mice (J:166099)
• heminodes fail to form unlike in wild-type mice (J:166099)
• however, nodes form normally (J:166099)




Genotype
MGI:4461155
hm4
Allelic
Composition
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129S6/SvEvTac * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• males and females display a longer latency to reach the escape platform in the reversal phase (J:153165)
• males and females display a longer latency to reach the escape platform in the reversal phase (J:153165)
• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials (J:153165)
• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials (J:153165)
• females but not males display a longer latency to find a hidden platform (J:153165)
• females but not males display a longer latency to find a hidden platform (J:153165)
• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females (J:153165)
• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females (J:153165)
• decrease in rearing frequency in an open field in females (J:153165)
• decrease in rearing frequency in an open field in females (J:153165)
• males fail to show a preference for a stranger mouse over an empty cage (J:153165)
• males fail to show a preference for a stranger mouse over an empty cage (J:153165)

nervous system
• small but significant decrease in males (J:153165)
• small but significant decrease in males (J:153165)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:153165




Genotype
MGI:4840024
cx5
Allelic
Composition
Nfasctm1.1Brp/Nfasctm1.1Brp
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasctm1.1Brp mutation (0 available); any Nfasc mutation (8 available)
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• sodium ion channels are absent from heminodes unlike in wild-type mice (J:166099)
• sodium ion channels are absent from heminodes unlike in wild-type mice (J:166099)




Genotype
MGI:4840027
cx6
Allelic
Composition
Cntnap1tm1Pele/Cntnap1tm1Pele
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129P2/OlaHsd * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntnap1tm1Pele mutation (0 available); any Cntnap1 mutation (9 available)
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at P8 (J:166099)
• at P8 (J:166099)

nervous system
• nodes and heminodes fail to form unlike in wild-type mice (J:166099)
• nodal length is increased compared to in wild-type mice (J:166099)
• nodes and heminodes fail to form unlike in wild-type mice (J:166099)
• nodal length is increased compared to in wild-type mice (J:166099)
• at P7 (J:166099)
• at P7 (J:166099)

behavior/neurological
• strong congenital at P4 (J:166099)
• strong congenital at P4 (J:166099)




Genotype
MGI:3806025
cx7
Allelic
Composition
L1camtm1Sor/L1cam+
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1camtm1Sor mutation (2 available); any L1cam mutation (4 available)
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increase in rate of postnatal death, especially during the first 1-2 weeks after birth (J:71828)
• increase in rate of postnatal death, especially during the first 1-2 weeks after birth (J:71828)




Genotype
MGI:3806030
cx8
Allelic
Composition
L1camtm1Sor/Y
Nrcamtm1Gmt/Nrcam+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1camtm1Sor mutation (2 available); any L1cam mutation (4 available)
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increase in rate of postnatal death, especially during the first 1-2 weeks after birth (J:71828)
• increase in rate of postnatal death, especially during the first 1-2 weeks after birth (J:71828)




Genotype
MGI:3806032
cx9
Allelic
Composition
L1camtm1Sor/Y
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1camtm1Sor mutation (2 available); any L1cam mutation (4 available)
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cerebellar abnormalities in L1camtm1Sor/Y Nrcamtm1Gmt/Nrcamtm1Gmt mice

mortality/aging
• do not detect any mutants at P8 (J:71828)
• do not detect any mutants at P8 (J:71828)

growth/size/body
• body weights of pups are 40-70% of control littermates at P3-P6 (J:71828)
• body weights of pups are 40-70% of control littermates at P3-P6 (J:71828)

nervous system
• cerebellar dysgenesis (J:71828)
• cerebellar fissures are less developed (J:71828)
• thickness of the inner granule layer is reduced by 40-50% (J:71828)
• cerebellar dysgenesis (J:71828)
• cerebellar fissures are less developed (J:71828)
• thickness of the inner granule layer is reduced by 40-50% (J:71828)
• marker analysis indicates defects in foliation (J:71828)
• marker analysis indicates defects in foliation (J:71828)
• thickness of the external granule layer is reduced by 10-30% (J:71828)
• thickness of the external granule layer is reduced by 10-30% (J:71828)
• cerebellar lobes are less developed (J:71828)
• cerebellar lobes are less developed (J:71828)
• marker analysis indicates possible defects in granule cells during cerebellar development (J:71828)
• thickness of the inner granule layer is reduced by 40-50% (J:71828)
• thickness of the external granule layer is reduced by 10-30% (J:71828)
• marker analysis indicates possible defects in granule cells during cerebellar development (J:71828)
• thickness of the inner granule layer is reduced by 40-50% (J:71828)
• thickness of the external granule layer is reduced by 10-30% (J:71828)
(J:71828)
(J:71828)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory