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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcnc2tm1Rudy
targeted mutation 1, Bernardo Rudy
MGI:2387957
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcnc2tm1Rudy/Kcnc2tm1Rudy B6.129S1-Kcnc2tm1Rudy MGI:3583223


Genotype
MGI:3583223
hm1
Allelic
Composition
Kcnc2tm1Rudy/Kcnc2tm1Rudy
Genetic
Background
B6.129S1-Kcnc2tm1Rudy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnc2tm1Rudy mutation (0 available); any Kcnc2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• spontaneous seizures characterized as tonic-clonic convulsions
• spontaneous seizures characterized as tonic-clonic convulsions
• low level of spontaneous epileptic episodes
• 14 mice out of several hundred handled
• fast-spike cortical interneurons from deep layers but not superficial layers with broader action potentials and slower repolarization
• fast-spike neurons unable to sustain high frequencies of firing with repetitive stimulation
• unable to generate rhythmic spike doublets on stimulation
• reduced by about 25% and slower
• irregular EEG slow rhythm

behavior/neurological
• center/distance ratio is lower in open field tests
• lower frequency of NREM and REM sleep although episode duration was normal
• lower EEG power density in NREM sleep, also in the frontal derivation during REM sleep
• spontaneous seizures characterized as tonic-clonic convulsions
• spontaneous seizures characterized as tonic-clonic convulsions
• low level of spontaneous epileptic episodes
• 14 mice out of several hundred handled

muscle
• spontaneous seizures characterized as tonic-clonic convulsions





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory