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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ogttm1Gwh
targeted mutation 1, Gerald W Hart
MGI:2387867
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ogttm1Gwh/Y involves: 129S1/Sv * 129X1/SvJ MGI:3841624
cn2
Ogttm1Gwh/Ogt+
Tg(Prm-cre)58Og/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3841629
cn3
Ogttm1Gwh/Ogttm1Gwh
Tg(Zp3-cre)1Gwh/0
involves: 129S1/Sv * 129X1/SvJ MGI:3841621
cn4
Ogttm1Gwh/Ogt+
Tg(Zp3-cre)1Gwh/0
involves: 129S1/Sv * 129X1/SvJ MGI:3841622
cn5
Ogttm1Gwh/Y
Tg(Zp3-cre)1Gwh/0
involves: 129S1/Sv * 129X1/SvJ MGI:3841623
cn6
Ogttm1Gwh/Y
Tg(Lck-cre)548Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3841625
cn7
Ogttm1Gwh/Y
Tg(Syn1-cre)671Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3841626
cn8
Ogttm1Gwh/Ogttm1Gwh
Tg(Syn1-cre)671Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3841627


Genotype
MGI:3841624
cn1
Allelic
Composition
Ogttm1Gwh/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• recombined embryonic stem cells are found at 24 and 48 h following cre transduction but by 144 h all viable cells carry the unrecombined allele (J:62279)
• primary embryonic fibroblasts infected with viral cre senesce and die by 12 days after infection (J:93112)
• primary embryonic fibroblasts infected with viral cre do not form colonies of more than 10 cells indicating a failure to undergo 4 or more cell divisions




Genotype
MGI:3841629
cn2
Allelic
Composition
Ogttm1Gwh/Ogt+
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
Tg(Prm-cre)58Og mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile with no gross abnormalities and expression levels of Ogt that are similar to controls suggesting inactivation of the paternal X chromosome in all tissues and cell types surveyed
• mice do not produce any offspring carrying the recombined allele




Genotype
MGI:3841621
cn3
Allelic
Composition
Ogttm1Gwh/Ogttm1Gwh
Tg(Zp3-cre)1Gwh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
Tg(Zp3-cre)1Gwh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when the cre is inherited maternally, no mice carrying the recombined allele are detected

reproductive system
• when the cre is inherited paternally mice survive but females are infertile




Genotype
MGI:3841622
cn4
Allelic
Composition
Ogttm1Gwh/Ogt+
Tg(Zp3-cre)1Gwh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
Tg(Zp3-cre)1Gwh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice carrying the recombined allele are detected




Genotype
MGI:3841623
cn5
Allelic
Composition
Ogttm1Gwh/Y
Tg(Zp3-cre)1Gwh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
Tg(Zp3-cre)1Gwh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice carrying the recombined allele are detected




Genotype
MGI:3841625
cn6
Allelic
Composition
Ogttm1Gwh/Y
Tg(Lck-cre)548Jxm/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in annexin-V expression in single positive T cells
• about a 75% reduction in the number of T cells in the lymph nodes and spleen
• no T cells carrying the recombined allele are found in the lymph nodes or spleen
• about a 50% reduction in thymocyte cell number
• cortical double positive T cells are reduced by 50%

hematopoietic system
• increase in annexin-V expression in single positive T cells
• about a 75% reduction in the number of T cells in the lymph nodes and spleen
• no T cells carrying the recombined allele are found in the lymph nodes or spleen
• about a 50% reduction in thymocyte cell number
• cortical double positive T cells are reduced by 50%

cellular
• increase in annexin-V expression in single positive T cells

endocrine/exocrine glands
• about a 50% reduction in thymocyte cell number




Genotype
MGI:3841626
cn7
Allelic
Composition
Ogttm1Gwh/Y
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• none survive for more than 10 days
• found at only about 50% of the expected frequency

behavior/neurological
• rarely nurse
• fail to develop normal locomotor activity

growth/size/body




Genotype
MGI:3841627
cn8
Allelic
Composition
Ogttm1Gwh/Ogttm1Gwh
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (1 available); any Ogt mutation (9 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• none survive for more than 10 days

behavior/neurological
• rarely nurse
• fail to develop normal locomotor activity

growth/size/body





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory