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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Clip2tm1.1Gal
targeted mutation 1.1, Niels Galjart
MGI:2387833
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Clip2tm1.1Gal/Clip2tm1.1Gal involves: 129P2/OlaHsd * C57BL/6 MGI:3620029
ht2
Clip2tm1.1Gal/Clip2+ involves: 129P2/OlaHsd * C57BL/6 MGI:3620031


Genotype
MGI:3620029
hm1
Allelic
Composition
Clip2tm1.1Gal/Clip2tm1.1Gal
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clip2tm1.1Gal mutation (1 available); any Clip2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• adult female weight is 15% lower than in wild-type (J:78711)
• adult female weight is 15% lower than in wild-type (J:78711)
• 11% decrease in adult female body length (J:78711)
• 11% decrease in adult female body length (J:78711)
• seen in both males and females (J:78711)
• seen in both males and females (J:78711)

nervous system
• average brain-ventricle volume is larger (J:78711)
• average brain-ventricle volume is larger (J:78711)
• average corpus callosum volume is smaller (J:78711)
• average corpus callosum volume is smaller (J:78711)
• synaptic plasticity in the hippocampal CA1 region is lower (J:78711)
• synaptic plasticity in the hippocampal CA1 region is lower (J:78711)

behavior/neurological
N
• no differences from wild-type are seen in spontaneous locomotion, the hanging wire test measuring balance and grip strength, the beam-walk test, and compensatory eye movements during visual or vestibular stimulation (J:78711)
• no differences from wild-type are seen in spontaneous locomotion, the hanging wire test measuring balance and grip strength, the beam-walk test, and compensatory eye movements during visual or vestibular stimulation (J:78711)
• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects (J:78711)
• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects (J:78711)
• remain on an accelerating rotarod for significantly shorter periods and exhibit poor initial coordination on a running wheel, showing highly erratic motions and occasional ejection from the wheel (J:78711)
• remain on an accelerating rotarod for significantly shorter periods and exhibit poor initial coordination on a running wheel, showing highly erratic motions and occasional ejection from the wheel (J:78711)

cellular
• fibroblasts exhibit a higher level of dynactin and restin at microtubule tips, however observe no differences in microtubule dynamics (J:78711)
• fibroblasts exhibit a higher level of dynactin and restin at microtubule tips, however observe no differences in microtubule dynamics (J:78711)

skeleton
• lower weight in females is paralleled by shorter bone lengths, however observe no craniofacial irregularities (J:78711)
• lower weight in females is paralleled by shorter bone lengths, however observe no craniofacial irregularities (J:78711)




Genotype
MGI:3620031
ht2
Allelic
Composition
Clip2tm1.1Gal/Clip2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clip2tm1.1Gal mutation (1 available); any Clip2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• adult female weight is 9% lower than in wild-type (J:78711)
• adult female weight is 9% lower than in wild-type (J:78711)
• mild growth retardation during the first weeks of postnatal development that persists in adult females (J:78711)
• mild growth retardation during the first weeks of postnatal development that persists in adult females (J:78711)

nervous system
• average corpus callosum volume is smaller, however ventricle volumes are normal (J:78711)
• average corpus callosum volume is smaller, however ventricle volumes are normal (J:78711)
• synaptic plasticity in the hippocampal CA1 region is lower (J:78711)
• synaptic plasticity in the hippocampal CA1 region is lower (J:78711)

behavior/neurological
• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects (J:78711)
• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects (J:78711)
• remain on an accelerating rotarod for significantly shorter periods (J:78711)
• remain on an accelerating rotarod for significantly shorter periods (J:78711)

Mouse Models of Human Disease
OMIM ID Ref(s)
Williams-Beuren Syndrome; WBS 194050 J:78711





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory