Phenotypes associated with this allele

• Allele Symbol: Nmbr^tm1Hoh
• Allele Name: targeted mutation 1, Hiroko Ohki-Hamazaki
• Allele ID: MGI:2387767
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmbr^tm1Hoh/Nmbr^tm1Hoh	involves: 129P2/OlaHsd * C57BL/6J	MGI:3623258
cx2	Grpr^tm1Jfb/Grpr^tm1Jfb Nmbr^tm1Hoh/Nmbr^tm1Hoh	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:6111349

Genotype
MGI:3623258

hm1

• Allelic Composition: Nmbr^tm1Hoh/Nmbr^tm1Hoh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal body temperature homeostasis ( J:52410 )

• in response to treatment with neuromedin B, male and female mutants exhibit smaller decreases in rectal temperature than wild-type mice; thermoregulatory response to neuromedin is decreased by 50%

behavior/neurological

abnormal maternal nurturing ( J:108035 )

♀ • stressed virgin null females show limited and incomplete maternal behavior compared with stressed wild-type virgin females or non-stressed virgin null females

Genotype
MGI:6111349

cx2

• Allelic Composition: Grpr^tm1Jfb/Grpr^tm1Jfb; Nmbr^tm1Hoh/Nmbr^tm1Hoh
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

behavior/neurological

behavior/neurological phenotype ( J:253572 )

N • mice exhibit normal responses to a wide array of noxious stimuli