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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fut7tm1Jbl
targeted mutation 1, John Lowe
MGI:2387664
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fut7tm1Jbl/Fut7tm1Jbl B6.129S2-Fut7tm1Jbl MGI:3620056
hm2
Fut7tm1Jbl/Fut7tm1Jbl involves: 129S2/SvPas * C57BL/6J * DBA/2J MGI:3620053
cx3
Fut4tm1Jbl/Fut4tm1Jbl
Fut7tm1Jbl/Fut7tm1Jbl
B6.129S2-Fut7tm1Jbl Fut4tm1Jbl MGI:3620054
cx4
Apoetm1Unc/Apoetm1Unc
Fut4tm1Jbl/Fut4tm1Jbl
Fut7tm1Jbl/Fut7tm1Jbl
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3652962


Genotype
MGI:3620056
hm1
Allelic
Composition
Fut7tm1Jbl/Fut7tm1Jbl
Genetic
Background
B6.129S2-Fut7tm1Jbl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fut7tm1Jbl mutation (1 available); any Fut7 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• remain in circulation for an extended period of time
• deficient recruitment to the dermis in inflammation
• significantly reduced delayed type hypersensitivity (J:74776)
• contact hypersensitivity present even if reduced (J:79388)

neoplasm

hematopoietic system
• remain in circulation for an extended period of time
• deficient recruitment to the dermis in inflammation




Genotype
MGI:3620053
hm2
Allelic
Composition
Fut7tm1Jbl/Fut7tm1Jbl
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fut7tm1Jbl mutation (1 available); any Fut7 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• monocytes unable to bind E- or P-selectin
• homing of lymphocytes to peripheral lymph nodes is defective
• 80% reduction of lymphocytes in axillary and brachial lymph nodes
• ability of leukocytes to adhere to endothelial walls is deficient
• rolling leukocytes absent or rolling is abnormal
• unable to bind E- or P-selectin
• 6 fold reduction in migration to peritoneal cavity after induced peritonitis

hematopoietic system
• reduced numbers of splenic megakaryocytes
• monocytes unable to bind E- or P-selectin
• homing of lymphocytes to peripheral lymph nodes is defective
• 80% reduction of lymphocytes in axillary and brachial lymph nodes
• ability of leukocytes to adhere to endothelial walls is deficient
• rolling leukocytes absent or rolling is abnormal
• unable to bind E- or P-selectin
• 6 fold reduction in migration to peritoneal cavity after induced peritonitis

cellular
• homing of lymphocytes to peripheral lymph nodes is defective
• 80% reduction of lymphocytes in axillary and brachial lymph nodes
• ability of leukocytes to adhere to endothelial walls is deficient
• rolling leukocytes absent or rolling is abnormal




Genotype
MGI:3620054
cx3
Allelic
Composition
Fut4tm1Jbl/Fut4tm1Jbl
Fut7tm1Jbl/Fut7tm1Jbl
Genetic
Background
B6.129S2-Fut7tm1Jbl Fut4tm1Jbl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fut4tm1Jbl mutation (1 available); any Fut4 mutation (5 available)
Fut7tm1Jbl mutation (1 available); any Fut7 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 2.9 fold increase in circulating leukocytes
• 18 fold increase in neutrophiles
• increased production of neurophiles
• reduced lymphocyte homing to peripheral and mesenteric lymph nodes
• migration to Peyer's patches unaffected
• remain in circulation for an extremely long period of time
• unable to bind E- or P-selectins
• absent recruitment to the dermis in inflammation
• small and infrequent but lymph node architecture is otherwise normal
• peripheral lymph nodes are small
• 95% reduction of cellularity in peripheral lymph nodes (J:79388)
• reduced lymphocyte content (J:79397)
• binding of A. phagocytophilum to neutrophils is severely reduced compared to in wild-type mice
• chemokine secretion induced by infection with A. phagocytophilum is reduced compared to in wild-type and Selplgtm1Rpmc neutrophils

hematopoietic system
• 2.9 fold increase in circulating leukocytes
• 18 fold increase in neutrophiles
• increased production of neurophiles
• reduced lymphocyte homing to peripheral and mesenteric lymph nodes
• migration to Peyer's patches unaffected
• remain in circulation for an extremely long period of time
• unable to bind E- or P-selectins
• absent recruitment to the dermis in inflammation

cellular
• reduced lymphocyte homing to peripheral and mesenteric lymph nodes
• migration to Peyer's patches unaffected




Genotype
MGI:3652962
cx4
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Fut4tm1Jbl/Fut4tm1Jbl
Fut7tm1Jbl/Fut7tm1Jbl
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (146 available)
Fut4tm1Jbl mutation (1 available); any Fut4 mutation (5 available)
Fut7tm1Jbl mutation (1 available); any Fut7 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• decreased lesion size at 6 months of age





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory