Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fut7tm1Jbl mutation
(1 available);
any
Fut7 mutation
(14 available)
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immune system
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• remain in circulation for an extended period of time
• deficient recruitment to the dermis in inflammation
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• significantly reduced delayed type hypersensitivity
(J:74776)
• contact hypersensitivity present even if reduced
(J:79388)
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neoplasm
hematopoietic system
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• remain in circulation for an extended period of time
• deficient recruitment to the dermis in inflammation
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Allelic Composition |
Fut7tm1Jbl/Fut7tm1Jbl
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Genetic Background |
involves: 129S2/SvPas * C57BL/6J * DBA/2J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fut7tm1Jbl mutation
(1 available);
any
Fut7 mutation
(14 available)
|
|
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immune system
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• monocytes unable to bind E- or P-selectin
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• homing of lymphocytes to peripheral lymph nodes is defective
• 80% reduction of lymphocytes in axillary and brachial lymph nodes
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• ability of leukocytes to adhere to endothelial walls is deficient
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• rolling leukocytes absent or rolling is abnormal
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• unable to bind E- or P-selectin
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• 6 fold reduction in migration to peritoneal cavity after induced peritonitis
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hematopoietic system
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• reduced numbers of splenic megakaryocytes
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• monocytes unable to bind E- or P-selectin
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• homing of lymphocytes to peripheral lymph nodes is defective
• 80% reduction of lymphocytes in axillary and brachial lymph nodes
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• ability of leukocytes to adhere to endothelial walls is deficient
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• rolling leukocytes absent or rolling is abnormal
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• unable to bind E- or P-selectin
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• 6 fold reduction in migration to peritoneal cavity after induced peritonitis
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cellular
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• homing of lymphocytes to peripheral lymph nodes is defective
• 80% reduction of lymphocytes in axillary and brachial lymph nodes
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• ability of leukocytes to adhere to endothelial walls is deficient
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• rolling leukocytes absent or rolling is abnormal
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immune system
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• 2.9 fold increase in circulating leukocytes
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• 18 fold increase in neutrophiles
• increased production of neurophiles
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• reduced lymphocyte homing to peripheral and mesenteric lymph nodes
• migration to Peyer's patches unaffected
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• remain in circulation for an extremely long period of time
• unable to bind E- or P-selectins
• absent recruitment to the dermis in inflammation
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• small and infrequent but lymph node architecture is otherwise normal
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• peripheral lymph nodes are small
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• 95% reduction of cellularity in peripheral lymph nodes
(J:79388)
• reduced lymphocyte content
(J:79397)
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• no hypersensitive response
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• binding of A. phagocytophilum to neutrophils is severely reduced compared to in wild-type mice
• chemokine secretion induced by infection with A. phagocytophilum is reduced compared to in wild-type and Selplgtm1Rpmc neutrophils
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hematopoietic system
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• 2.9 fold increase in circulating leukocytes
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• 18 fold increase in neutrophiles
• increased production of neurophiles
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• reduced lymphocyte homing to peripheral and mesenteric lymph nodes
• migration to Peyer's patches unaffected
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• remain in circulation for an extremely long period of time
• unable to bind E- or P-selectins
• absent recruitment to the dermis in inflammation
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cellular
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• reduced lymphocyte homing to peripheral and mesenteric lymph nodes
• migration to Peyer's patches unaffected
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cardiovascular system
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• decreased lesion size at 6 months of age
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