About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adra1atm1Pcs
targeted mutation 1, Paul C Simpson
MGI:2387663
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adra1atm1Pcs/Adra1atm1Pcs involves: 129X1/SvJ * FVB/N MGI:2653821
ht2
Adra1atm1Pcs/Adra1a+ involves: 129X1/SvJ * FVB/N MGI:3625478
cx3
Adra1atm1Pcs/Adra1atm1Pcs
Adra1btm1Cta/Adra1btm1Cta
B6.129-Adra1btm1Cta Adra1atm1Pcs MGI:3689510
cx4
Adra1atm1Pcs/Adra1atm1Pcs
Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N MGI:3689509


Genotype
MGI:2653821
hm1
Allelic
Composition
Adra1atm1Pcs/Adra1atm1Pcs
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adra1atm1Pcs mutation (1 available); any Adra1a mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• by ECG telemetry, conscious homozygotes show a 14% reduction in basal heart rate variability, suggesting increased sympathetic balance
• by tail cuff manometer and arterial catheter, conscious homozygotes are hypotensive at rest, with a ~10-15 mm Hg reduction in blood pressure (8-12% of wild-type mice)
• tail cuff pressure is also reduced in a smaller cohort of homozygotes in the C57BL/6 background whereas heart rate is slightly but not significantly higher relative to wild-type mice
• no differences in body weight, heart weight, heart histology, blood chemistry, blood cell counts, cardiac output or renal function are observed
• homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone

muscle
• homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone




Genotype
MGI:3625478
ht2
Allelic
Composition
Adra1atm1Pcs/Adra1a+
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adra1atm1Pcs mutation (1 available); any Adra1a mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• heterozygotes are intermediately hypotensive relative to wild-type and homozygous mutant mice




Genotype
MGI:3689510
cx3
Allelic
Composition
Adra1atm1Pcs/Adra1atm1Pcs
Adra1btm1Cta/Adra1btm1Cta
Genetic
Background
B6.129-Adra1btm1Cta Adra1atm1Pcs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adra1atm1Pcs mutation (1 available); any Adra1a mutation (17 available)
Adra1btm1Cta mutation (1 available); any Adra1b mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• myocyte cross-sectional area and surface area are 25% smaller in males than in wild-type
• hearts are smaller in males, but not females, due to smaller myocytes

muscle
• myocyte cross-sectional area and surface area are 25% smaller in males than in wild-type




Genotype
MGI:3689509
cx4
Allelic
Composition
Adra1atm1Pcs/Adra1atm1Pcs
Adra1btm1Cta/Adra1btm1Cta
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adra1atm1Pcs mutation (1 available); any Adra1a mutation (17 available)
Adra1btm1Cta mutation (1 available); any Adra1b mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females exhibit larger kidneys than wild-type

mortality/aging
• males show increased mortality after pressure overload (transverse aortic constriction), with only 56% surviving 14 days post TAC

cardiovascular system
• myocyte cross-sectional area is reduced by 33% in male hearts
• hearts are smaller in males, but not females, due to smaller myocytes
• male atrial, ventricular, and total heart wet weights are reduced by 18%, 16%, and 16%, respectively, however females have normal sized hearts
• male heart growth after weaning is 40% less than in wild-type
• cardiac output is reduced by 27% in conscious males
• conscious males show a 20% reduction in end-diastolic volume which causes a smaller stroke volume
• ventricular trabeculae have higher submaximal force at 2 mM extracellular calcium concentration than wild-type, however peaks of fura-2 calcium transients are not different, suggesting the myocardium has increased myofilament calcium sensitivity
• ventricular trabeculae have lower maximal force than wild-type at high extracellular calcium concentrations (6 mM), however peak cystolic calcium concentration is not different
• maximum tetanic force of trabeculae is lower than in wild-type
• trabeculae develop higher forces at all pacing rates tested than wild-type
• in anesthetized males, but not conscious males, indices of contractility (fractional shortening and ejection fraction) are increased slightly and left ventricular wall thickness and mass and end-systolic chamber size are reduced and the left ventricle end-diastolic chamber size tends to be smaller
• 2.5 mM calcium Langendorff-perfused hearts have higher developed pressure than wild-type
• conscious young males and females show reduced heart rate, although blood pressure is normal and anesthetized mice show no difference in heart rate
• myocardium shows increased myofilament calcium-sensitivity and decreased responsiveness to beta-adrenergic stimulation
• males show increased mortality and heart failure after pressure overload
• heart failure is seen in males exposed to pressure overload

homeostasis/metabolism
• males run significantly less in both a voluntary and forced exercise test, indicating reduced exercise capacity
• males show increased mortality and heart failure after pressure overload

muscle
• myocyte cross-sectional area is reduced by 33% in male hearts
• ventricular trabeculae have higher submaximal force at 2 mM extracellular calcium concentration than wild-type, however peaks of fura-2 calcium transients are not different, suggesting the myocardium has increased myofilament calcium sensitivity
• ventricular trabeculae have lower maximal force than wild-type at high extracellular calcium concentrations (6 mM), however peak cystolic calcium concentration is not different
• maximum tetanic force of trabeculae is lower than in wild-type
• trabeculae develop higher forces at all pacing rates tested than wild-type
• in anesthetized males, but not conscious males, indices of contractility (fractional shortening and ejection fraction) are increased slightly and left ventricular wall thickness and mass and end-systolic chamber size are reduced and the left ventricle end-diastolic chamber size tends to be smaller

renal/urinary system
• females exhibit larger kidneys than wild-type

behavior/neurological
• males run significantly less in both a voluntary and forced exercise test, indicating reduced exercise capacity





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/10/2020
MGI 6.16
The Jackson Laboratory