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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Wnt7btm1Parr
targeted mutation 1, Brian A Parr
MGI:2387443
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Wnt7btm1Parr/Wnt7btm1Parr involves: 129S1/Sv MGI:2653625
cn2
Twist2tm1(cre)Dor/Twist2+
Wnt7btm1Parr/Wnt7btm2Amc
involves: 129S1/Sv * 129X1/SvJ MGI:3841730
cn3
Edil3Tg(Sox2-cre)1Amc/Edil3+
Wnt7atm1Amc/Wnt7atm1Amc
Wnt7btm1Parr/Wnt7btm2Amc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3831189
cn4
Tg(Nes-cre)1Kln/0
Wnt7atm1Amc/Wnt7atm1Amc
Wnt7btm1Parr/Wnt7btm2Amc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3831188


Genotype
MGI:2653625
hm1
Allelic
Composition
Wnt7btm1Parr/Wnt7btm1Parr
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt7btm1Parr mutation (1 available); any Wnt7b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo




Genotype
MGI:3841730
cn2
Allelic
Composition
Twist2tm1(cre)Dor/Twist2+
Wnt7btm1Parr/Wnt7btm2Amc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (8 available)
Wnt7btm1Parr mutation (1 available); any Wnt7b mutation (11 available)
Wnt7btm2Amc mutation (1 available); any Wnt7b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• calvaria cells from neonates and bone marrow stromal cells from adults produce fewer bone nodules than wild-type cells
• at E15.5, ossification if diminished compared to in wild-type mice
• bone collars of long bones are shorter than in wild-type mice
• at E18.5, skulls exhibit decreased ossification compared to in wild-type mice

cellular
• calvaria cells from neonates and bone marrow stromal cells from adults produce fewer bone nodules than wild-type cells




Genotype
MGI:3831189
cn3
Allelic
Composition
Edil3Tg(Sox2-cre)1Amc/Edil3+
Wnt7atm1Amc/Wnt7atm1Amc
Wnt7btm1Parr/Wnt7btm2Amc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (36 available)
Wnt7atm1Amc mutation (1 available); any Wnt7a mutation (23 available)
Wnt7btm1Parr mutation (1 available); any Wnt7b mutation (11 available)
Wnt7btm2Amc mutation (1 available); any Wnt7b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system
• while vascularization has occurred within the ventral neural tube of control E10.5 embryos at the forelimb level, no such vascularization is observed in this region of mutant embryos
• in E12.5 embryos, endothelial cells and pericytes are absent from all ventral neural regions of the presumptive spinal cord except for in the floor plate
• in the dorsal neural tube of E12.5 embryos, endothelial cells and pericytes form abnormal clusters and enlarged lumens in the vascular structures present
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos




Genotype
MGI:3831188
cn4
Allelic
Composition
Tg(Nes-cre)1Kln/0
Wnt7atm1Amc/Wnt7atm1Amc
Wnt7btm1Parr/Wnt7btm2Amc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Wnt7atm1Amc mutation (1 available); any Wnt7a mutation (23 available)
Wnt7btm1Parr mutation (1 available); any Wnt7b mutation (11 available)
Wnt7btm2Amc mutation (1 available); any Wnt7b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system
• the number of endothelial cells and pericytes present in the intraneural vascular plexus of E12.5 embryos is greatly reduced
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory