Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1tm2.1Stl mutation
(0 available);
any
Chrm1 mutation
(26 available)
Tg(Grik4-cre)G32-4Stl mutation
(1 available)
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nervous system
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• excitatory postsynaptic currents from hippocampal slices are higher than in wild-type
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• (S)-3,5-dihydroxyphenylglycine hydrate (DHPG), an mGluR agonist, fails to produce long-term depression in hippocampal slices
• pretreatment of hippocampal slices with PKC activator 12-O-tetradecanoylphorbol 13-acetate, restores DHPG long-term
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm1Vyb mutation
(1 available);
any
Camk2a mutation
(136 available)
Tg(Grik4-cre)G32-4Stl mutation
(1 available)
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nervous system
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• mutants exhibit normal basal neurotransmitter release at CA3-CA1 synapses but show an enhanced activity-dependent increase in the probability of release during repetitive presynaptic stimulation
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• although synaptic depression is normal, the initial facilitation of the EPSC amplitude during repetitive stimulation of synaptic inputs (frequency facilitation) is significantly enhanced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm2Stl mutation
(1 available);
any
Grin1 mutation
(64 available)
Tg(Grik4-cre)G32-4Stl mutation
(1 available)
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behavior/neurological
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• impaired spatial memory recall after partial cue removal but not under full cue conditions in the Morris water maze and mutants exhibited normal motivation, motor coordination and sensory functions
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nervous system
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• CA1 pyramidal cells showed a significant decrease in complex spike bursting properties (complex spike index and burst spike frequency) when mutants were engaged in open-field foraging
• CA1 cells showed significant reductions in burst spike frequency, place field size and integrated firing rate after partial cue removal, however showed no significant changes when mutants were returned to an environment with all the distal cues present
• decreased firing rate of putative CA1 interneurons
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• the 6-cyano-7-dinitroquinoxalline-2,3-dione (DNQX)-insensitive component of the NMDA current was significantly reduced at the recurrent commissural/associational synapse relative to controls
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• long term potentiation was nearly absent at the commissural/associational (CA)-CA3 synapses in 9/11 mutants
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Analysis Tools