Mouse Genome Informatics
hm1
    Htr1atm1Rhn/Htr1atm1Rhn
129S6/SvEvTac-Htr1atm1Rhn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• in homozygotes, the noradrenaline (NA) content is elevated in olfactory bulb (+74%), thalamus (57%), substantia nigra (+63%), and cerebellum (+52%)
• dopamine (DA) levels are increased in caudate-putamen (+55%), 3,4-dihydroxyphenylacetic acid (DOPAC) in olfactory bulb (+120%), and homovanillic acid (HVA) in substantia nigra (+59%)
• in spite of the DA and 3-methoxytyramine (3-MT) increases in caudate-putamen, DA turnover ([DA metabolites]/[DA]) remains unaltered in this region
• notably, DA turnover is significantly increased in olfactory bulb (+81%) and substantia nigra (+88%), as well as in the dorsal/medial raphe nuclei (+89%)
• notably, 5-hydroxyindole-3-acetic acid (5-HIAA) content is increased significantly in olfactory bulb (+193%), substantia nigra (+133%), dorsal/medial raphe nuclei (+110%), locus coeruleus (+86%), and thalamus (+47%) (J:65662)
• levels of 5-hydroxytryptophol (5-HTOL) are increased in substantia nigra (+124%), dorsal/medial raphe nuclei (+105%), and probably locus coeruleus (+61%), but not in olfactory bulb (J:65662)
• high [5-HT metabolites]/[5-HT] ratios indicate that 5-HT turnover is increased considerably in olfactory bulb (+87%), substantia nigra (+138%), dorsal/medial nuclei (+79%), and locus coeruleus (+103%) (J:65662)
• importantly, mutants show a significant reduction in density of 5-HTT binding in several brain regions, including parts of the cerebral cortex, limbic system, thalamus and basal ganglia (J:70686)

nervous system
N
• homozygotes show only a few significant differences in regional serotonin concentration throughout the brain and spinal cord (J:65662)
• homozygous mutants do not display any compensatory changes in HTR1B density (J:70686)
• homozygotes have a normal density of serotonin transporter (5-HTT) binding in the raphe nuclei, i.e. in serotonin somata/dendrites (J:70686)
• dopamine (DA) levels are increased in caudate-putamen (+55%), 3,4-dihydroxyphenylacetic acid (DOPAC) in olfactory bulb (+120%), and homovanillic acid (HVA) in substantia nigra (+59%)
• in spite of the DA and 3-methoxytyramine (3-MT) increases in caudate-putamen, DA turnover ([DA metabolites]/[DA]) remains unaltered in this region
• notably, DA turnover is significantly increased in olfactory bulb (+81%) and substantia nigra (+88%), as well as in the dorsal/medial raphe nuclei (+89%)


Mouse Genome Informatics
hm2
    Htr1atm1Rhn/Htr1atm1Rhn
involves: 129S/SvEv * 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological

nervous system
• in the elevated plus maze and open field, mutants exhibit a larger increase in medial prefrontal cortex theta power than wild-type mice
• however, no differences in theta power in the ventral or dorsal hippocampus are observed

Mouse Models of Human Disease
OMIM IDRef(s)
Anxiety 607834 J:167655


Mouse Genome Informatics
hm3
    Htr1atm1Rhn/Htr1atm1Rhn
involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• in the forced swim test, homozygotes are significantly more active than wild-type, particularly during the last 10 min of the test
• homozygotes appear to display less behavioral despair than wild-type littermates; whereas wild-type mice become progressively more immobile, homozygous mutants maintain the same level of activity throughout the swim test
• in the open field, homozygotes exhibit decreased exploratory activity and increased anxious-like behavior relative to wild-type
• in the elevated plus maze, homozygotes display significantly more anxiety-like behaviors with no significant changes in activity
• homozygous null males appear to be affected more than females, particularly in some measures of anxiety

Mouse Models of Human Disease
OMIM IDRef(s)
Anxiety 607834 J:51280


Mouse Genome Informatics
ht4
    Htr1atm1Rhn/Htr1a+
involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• relative to homozygotes, heterozygotes, which express ~50% of wild-type receptor density, display intermediate phenotypes in most behavioral tests