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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stk11tm1Rdp
targeted mutation 1, Ronald DePinho
MGI:2387401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Amhr2tm3(cre)Bhr/Amhr2+
Stk11tm1Rdp/Stk11tm1Rdp
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:5440238
cn2
Stk11tm1Rdp/Stk11tm1Rdp
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S6/SvEvTac * C57BL/6 MGI:5496896


Genotype
MGI:5440238
cn1
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Stk11tm1Rdp/Stk11tm1Rdp
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (14 available)
Stk11tm1Rdp mutation (1 available); any Stk11 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• progressive premature germ cell loss

reproductive system
• progressive premature germ cell loss
• testicular junction integrity is compromised
• by 5 months of age, mutants exhibit decreased tubular width accompanied by progressive germ cell loss and tubules with only Sertoli cells, indicating a Sertoli cell only phenotype
• at 4 weeks, vacuolization of seminiferous epithelium is seen in a few seminiferous tubules
• by 10 weeks of age, normal germ cell arrangement in the seminiferous tubules is disrupted and prominent vacuolization of the seminiferous epithelium is seen in most of the tubules
• sertoli cells show disruption of the spoke-like pattern of microtubules and loss of apical extensions, and disruption of actin filament arrangement, indicating disruption of polarity
• adult sertoli cells show disruption of cell cycle quiescence and thus increased proliferation in mice older than 4 months of age
• immature round germ cells are seen in the epididymides whereas only mature elongated germ cells are seen in controls indicating defective germ cell differentiation

endocrine/exocrine glands
• testicular junction integrity is compromised
• by 5 months of age, mutants exhibit decreased tubular width accompanied by progressive germ cell loss and tubules with only Sertoli cells, indicating a Sertoli cell only phenotype
• at 4 weeks, vacuolization of seminiferous epithelium is seen in a few seminiferous tubules
• by 10 weeks of age, normal germ cell arrangement in the seminiferous tubules is disrupted and prominent vacuolization of the seminiferous epithelium is seen in most of the tubules
• sertoli cells show disruption of the spoke-like pattern of microtubules and loss of apical extensions, and disruption of actin filament arrangement, indicating disruption of polarity
• adult sertoli cells show disruption of cell cycle quiescence and thus increased proliferation in mice older than 4 months of age

neoplasm
N
• testicular tumors are not observed up to 10 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Peutz-Jeghers Syndrome; PJS 175200 J:187754




Genotype
MGI:5496896
cn2
Allelic
Composition
Stk11tm1Rdp/Stk11tm1Rdp
Tg(MMTV-Erbb2*,-cre)1Mul/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk11tm1Rdp mutation (1 available); any Stk11 mutation (15 available)
Tg(MMTV-Erbb2*,-cre)1Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)
• 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

endocrine/exocrine glands
• tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors
• 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

integument
• tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors
• 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory