Mouse Genome Informatics
cn1
    Amhr2tm3(cre)Bhr/Amhr2+
Stk11tm1Rdp/Stk11tm1Rdp

involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• testicular junction integrity is compromised
• by 5 months of age, mutants exhibit decreased tubular width accompanied by progressive germ cell loss and tubules with only Sertoli cells, indicating a Sertoli cell only phenotype
• at 4 weeks, vacuolization of seminiferous epithelium is seen in a few seminiferous tubules
• by 10 weeks of age, normal germ cell arrangement in the seminiferous tubules is disrupted and prominent vacuolization of the seminiferous epithelium is seen in most of the tubules
• sertoli cells show disruption of the spoke-like pattern of microtubules and loss of apical extensions, and disruption of actin filament arrangement, indicating disruption of polarity
• adult sertoli cells show disruption of cell cycle quiescence and thus increased proliferation in mice older than 4 months of age
• progressive premature germ cell loss
• immature round germ cells are seen in the epididymides whereas only mature elongated germ cells are seen in controls indicating defective germ cell differentiation

endocrine/exocrine glands
• testicular junction integrity is compromised
• by 5 months of age, mutants exhibit decreased tubular width accompanied by progressive germ cell loss and tubules with only Sertoli cells, indicating a Sertoli cell only phenotype
• at 4 weeks, vacuolization of seminiferous epithelium is seen in a few seminiferous tubules
• by 10 weeks of age, normal germ cell arrangement in the seminiferous tubules is disrupted and prominent vacuolization of the seminiferous epithelium is seen in most of the tubules
• sertoli cells show disruption of the spoke-like pattern of microtubules and loss of apical extensions, and disruption of actin filament arrangement, indicating disruption of polarity
• adult sertoli cells show disruption of cell cycle quiescence and thus increased proliferation in mice older than 4 months of age