Phenotypes associated with this allele

• Allele Symbol: Foxe3^rct
• Allele Name: Rinshoken cataract
• Allele ID: MGI:2387330
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxe3^rct/Foxe3^rct	SJL/J-Foxe3^rct	MGI:5297581
cx2	Foxe3^rct/Foxe3^rct mrct/mrct	involves: SJL/J	MGI:2387333

Genotype
MGI:5297581

hm1

• Allelic Composition: Foxe3^rct/Foxe3^rct
• Genetic Background: SJL/J-Foxe3^rct

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Slit-lamp photographs of eyes of 4 month old SJL/J and rct/rct mice.

vision/eye

abnormal lens morphology ( J:177496 )

• at P0, lens nuclei localization is altered compared to in wild-type mice

• at P5, lenses contain many nuclei in the posterior compartments compared with wild-type mice

abnormal lens development ( J:177496 )

• at E14.5, the anterior region of the lens is disorganized where the lens epithelia is reduced compared to in wild-type mice

abnormal lens epithelium morphology ( J:177496 )

• at E14.5 and E15.5, lens epithelium is reduced compared to in wild-type mice

• at P0, the anterior lens epithelium is thinner than in wild-type mice

• at P28, lens epithelia exhibits a loss of gap junction

abnormal lens fiber morphology ( J:177496 )

• at P28, lens fibers contain huge vacuoles and loss of gap junction unlike in wild-type mice

disorganized secondary lens fibers ( J:177496 )

• at P5 and progressively more disorganized with time

cortical cataract ( J:177496 )

• within 3 months of birth

anterior polar cataract ( J:177496 )

• within 3 months of birth

Genotype
MGI:2387333

cx2

• Allelic Composition: Foxe3^rct/Foxe3^rct; mrct/mrct
• Genetic Background: involves: SJL/J

vision/eye

abnormal lens morphology ( J:68340 )

• lens degeneration

cataract ( J:68340 )

• observed at 3.5 months of age; onset controlled by the mrct gene

microphthalmia ( J:68340 )

• eyes 25% smaller than eyes of SJL/J control mice