Phenotypes associated with this allele

• Allele Symbol: Apc^tm1Hsa
• Allele Name: targeted mutation 1, Hitoshi Sasai
• Allele ID: MGI:2387050
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apc^tm1Hsa/Apc^tm1Hsa	involves: 129P2/OlaHsd * C57BL/6	MGI:3686783
ht2	Apc^tm1Hsa/Apc^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3686784

Genotype
MGI:3686783

hm1

• Allelic Composition: Apc^tm1Hsa/Apc^tm1Hsa
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:61978 )

• no homozygotes are found in born pups; time of lethality not specified

Genotype
MGI:3686784

ht2

• Allelic Composition: Apc^tm1Hsa/Apc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

integument

increased mammary gland tumor incidence ( J:61978 )

• some develop tumors in the mammary gland at 8 weeks of age

increased mammary adenocarcinoma incidence ( J:61978 )

• 18.5% develop a characteristic mammary tumor between 3 and 5 months of age, indicated as adenoacanthoma

mortality/aging

premature death ( J:61978 )

• die within 6 months of age due to severe anemia

cardiovascular system

intestinal hemorrhage ( J:61978 )

• develop normally until 2-3 months of age, when develop intestinal hemorrhage

hematopoietic system

anemia ( J:61978 )

• develop anemia after 2-3 months of age due to intestinal hemorrhage

neoplasm

increased gastrointestinal tumor incidence ( J:61978 )

• start to develop tumors mainly in the small intestine and some develop them in the colon, stomach, and duodenum at 8 weeks of age

• number of tumors in the intestine is variable and they appear sessile shaped with a central depression

increased stomach tumor incidence ( J:61978 )

increased mammary gland tumor incidence ( J:61978 )

• some develop tumors in the mammary gland at 8 weeks of age

increased mammary adenocarcinoma incidence ( J:61978 )

• 18.5% develop a characteristic mammary tumor between 3 and 5 months of age, indicated as adenoacanthoma

digestive/alimentary system

intestinal hemorrhage ( J:61978 )

• develop normally until 2-3 months of age, when develop intestinal hemorrhage

abnormal digestive system morphology ( J:61978 )

• large tumors sometimes cause stenosis of the gut and hemorrhage

abnormal crypts of Lieberkuhn morphology ( J:61978 )

• exhibit hyperproliferation of intestinal glands and mild cellular and structural abnormalities

colon polyps ( J:61978 )

• develop similar number of intestinal polyps as heterozygous Apc^Min and Apc^tm2Tno mice

increased gastrointestinal tumor incidence ( J:61978 )

• start to develop tumors mainly in the small intestine and some develop them in the colon, stomach, and duodenum at 8 weeks of age

• number of tumors in the intestine is variable and they appear sessile shaped with a central depression

increased stomach tumor incidence ( J:61978 )

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:61978 )

• exhibit hyperproliferation of intestinal glands and mild cellular and structural abnormalities

increased mammary gland tumor incidence ( J:61978 )

• some develop tumors in the mammary gland at 8 weeks of age

increased mammary adenocarcinoma incidence ( J:61978 )

• 18.5% develop a characteristic mammary tumor between 3 and 5 months of age, indicated as adenoacanthoma