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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apctm1Hsa
targeted mutation 1, Hitoshi Sasai
MGI:2387050
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apctm1Hsa/Apctm1Hsa involves: 129P2/OlaHsd * C57BL/6 MGI:3686783
ht2
Apctm1Hsa/Apc+ involves: 129P2/OlaHsd * C57BL/6 MGI:3686784


Genotype
MGI:3686783
hm1
Allelic
Composition
Apctm1Hsa/Apctm1Hsa
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Hsa mutation (0 available); any Apc mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygotes are found in born pups; time of lethality not specified




Genotype
MGI:3686784
ht2
Allelic
Composition
Apctm1Hsa/Apc+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Hsa mutation (0 available); any Apc mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• some develop tumors in the mammary gland at 8 weeks of age
• 18.5% develop a characteristic mammary tumor between 3 and 5 months of age, indicated as adenoacanthoma

mortality/aging
• die within 6 months of age due to severe anemia

cardiovascular system
• develop normally until 2-3 months of age, when develop intestinal hemorrhage

hematopoietic system
• develop anemia after 2-3 months of age due to intestinal hemorrhage

neoplasm
• start to develop tumors mainly in the small intestine and some develop them in the colon, stomach, and duodenum at 8 weeks of age
• number of tumors in the intestine is variable and they appear sessile shaped with a central depression
• some develop tumors in the mammary gland at 8 weeks of age
• 18.5% develop a characteristic mammary tumor between 3 and 5 months of age, indicated as adenoacanthoma

digestive/alimentary system
• develop normally until 2-3 months of age, when develop intestinal hemorrhage
• large tumors sometimes cause stenosis of the gut and hemorrhage
• exhibit hyperproliferation of intestinal glands and mild cellular and structural abnormalities
• develop similar number of intestinal polyps as heterozygous ApcMin and Apctm2Tno mice
• start to develop tumors mainly in the small intestine and some develop them in the colon, stomach, and duodenum at 8 weeks of age
• number of tumors in the intestine is variable and they appear sessile shaped with a central depression

endocrine/exocrine glands
• exhibit hyperproliferation of intestinal glands and mild cellular and structural abnormalities
• some develop tumors in the mammary gland at 8 weeks of age
• 18.5% develop a characteristic mammary tumor between 3 and 5 months of age, indicated as adenoacanthoma





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory