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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnase1tm1Tmo
targeted mutation 1, Tarik Moroy
MGI:2387029
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dnase1tm1Tmo/Dnase1tm1Tmo involves: 129P2/OlaHsd * C57BL/6 MGI:3639668
hm2
Dnase1tm1Tmo/Dnase1tm1Tmo involves: 129P2/OlaHsd * CD-1 MGI:3639676
ht3
Dnase1tm1Tmo/Dnase1+ involves: 129P2/OlaHsd * C57BL/6 MGI:3639669


Genotype
MGI:3639668
hm1
Allelic
Composition
Dnase1tm1Tmo/Dnase1tm1Tmo
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1tm1Tmo mutation (0 available); any Dnase1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some homozygotes display symptoms of systemic lupus erythematosus at 6-8 months of age and die

immune system
• 17/49 homozygotes exhibit splenomegaly
• Background Sensitivity: on a mixed 129/B6 background, mice develop symptoms similar to systemic lupus erythematosus
• mice show anti-nuclear antibodies
• 56% of male mice and 73% of female mice display anti-nuclear antibodies compared to 15% of male and 35% of female wild-type mice
• 21/49 show perivascular leukocytic infiltration in the kidney
• in males, 19% show glomerulonephritis compared to 0% of wild-type; 31% of female heterozygotes show glomerulonephritis compared to 12% in wild-type
• numbers in females are likely higher because numerous deficiet female animals could not be analyzed due to high autolysis

hematopoietic system
• 17/49 homozygotes exhibit splenomegaly

renal/urinary system
• 21/49 show perivascular leukocytic infiltration in the kidney
• in males, 19% show glomerulonephritis compared to 0% of wild-type; 31% of female heterozygotes show glomerulonephritis compared to 12% in wild-type
• numbers in females are likely higher because numerous deficiet female animals could not be analyzed due to high autolysis

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus; SLE 152700 J:62549




Genotype
MGI:3639676
hm2
Allelic
Composition
Dnase1tm1Tmo/Dnase1tm1Tmo
Genetic
Background
involves: 129P2/OlaHsd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1tm1Tmo mutation (0 available); any Dnase1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• after injection of cisplatin, mortality of null mice at days 3-4 is significantly reduced compared to wild-type

homeostasis/metabolism
• knockouts have decreased creatinine levels (0.9 mg/dl) compared to wild-type (2.7 mg/dl)
• knockouts have decreased BUN levels (125 mg/dl) compared to wild-type (250 mg/dl)
• after injection of cisplatin, mortality of null mice at days 3-4 is significantly reduced compared to wild-type

immune system
• Background Sensitivity: on a CD-1 background mice do not develop lupus but Dnase1-deficient mice on a 129 x C57BL/6 background do

renal/urinary system
• in null mice, no apoptotic bodies are observed while some are found in wild-type mice
• DNA fragmentation is significantly decreased in null mice after cisplatin treatment compared to wild-type mouse tissue
• necrosis is significantly decreased in Dnase1-null mice compared to wild-type after cisplatin treatment
• at day 4, wild-type mice show marked kidney failure, whereas knockouts are significantly protected

cellular
• in null mice, no apoptotic bodies are observed while some are found in wild-type mice
• DNA fragmentation is significantly decreased in null mice after cisplatin treatment compared to wild-type mouse tissue




Genotype
MGI:3639669
ht3
Allelic
Composition
Dnase1tm1Tmo/Dnase1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1tm1Tmo mutation (0 available); any Dnase1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some heterozygotes display symptoms of systemic lupus erythematosus at 6-8 months of age and die

immune system
• 10/66 heterozygotes exhibi splenomegaly
• mice show anti-nuclear antibodies
• 48% of male mice and 65% of female mice display anti-nuclear antibodies compared to 15% of male and 35% of wild-type mice
• 24/66 show perivascular leukocytic infiltration in the kidney
• in males, 15% show glomerulonephritis compared to 0% of wild-type; 19% of female heterozygotes show glomerulonephritis compared to 12% in wild-type

hematopoietic system
• 10/66 heterozygotes exhibi splenomegaly

renal/urinary system
• 24/66 show perivascular leukocytic infiltration in the kidney
• in males, 15% show glomerulonephritis compared to 0% of wild-type; 19% of female heterozygotes show glomerulonephritis compared to 12% in wild-type





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory