Mouse Genome Informatics
hm1
    Adcyap1tm1Nms/Adcyap1tm1Nms
B6.129-Adcyap1tm1Nms
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• litters born to female homozygotes are of normal size on the day of birth but show higher mortality than litters born to wild-type dams up to 21 days after birth

behavior/neurological
• 33% of female homozygotes have seminal plugs on more than one day in a 7-day pairing period, indicating abnormal mating patterns (J:131950)
• however, female homozygotes display normal puberty onset, estrous cycles, and seminal plugs when paired with a male of proven fertility (J:131950)

reproductive system
• only 13% of female homozygotes have implanted embryos 6.5 days after mating vs 81% of wild-type females (J:131950)
• only 21% of female homozygotes give birth to litters vs 100% of wild-type females (J:131950)
• in a pseudopregnancy test, only 40% of female homozygotes become pregnant and display a continuous diestrous, as expected; the remaining 60% continue cycling and fail to enter pseudopregnancy (J:131950)
• however, ovulation, ovarian histology, fertilization and first cleavage of released eggs appear normal (J:131950)

growth/size/body
• heterozygous litters born to female homozygotes show lower growth curves than litters born to wild-type dams
• litters initially display identical birth weights but those nursed by mutant dams show a significantly lower body weight at day 3, and this difference persists to day 9
• after day 9, litter weights stay equivalent between the two groups

homeostasis/metabolism
• on day 6.5 after mating, average prolactin levels of female homozygotes are reduced to ~30% of wild-type levels
• on day 6.5 after mating, average progesterone levels of female homozygotes are reduced to ~30% of wild-type levels


Mouse Genome Informatics
hm2
    Adcyap1tm1Nms/Adcyap1tm1Nms
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most dead by second week postnatal (J:71968)
• survival increased when housed at 24C (76% survived to day 14 postnatal vs. 11% at 21C) (J:79468)

adipose tissue
• subcutaneous white fat deposits totally depleted at death

growth/size/body
• after day 4 postnatal, failed to gain weight, then lost weight

homeostasis/metabolism
• in fasted state
• when removed from mothers, pups lost temperature faster than wild-type littermates

liver/biliary system
• micovesicular steatosis

muscle
• intracellular fat accumulation