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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lgals3tm1Ftl
targeted mutation 1, Fu-Tong Liu
MGI:2386938
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lgals3tm1Ftl/Lgals3tm1Ftl B6.129S2-Lgals3tm1Ftl MGI:3629701
hm2
Lgals3tm1Ftl/Lgals3tm1Ftl involves: 129S2/SvPas * C57BL/6 MGI:3629708
hm3
Lgals3tm1Ftl/Lgals3tm1Ftl involves: 129S2/SvPas * CD-1 MGI:5637814
cx4
Cys1cpk/Cys1cpk
Lgals3tm1Ftl/Lgals3tm1Ftl
B6.Cg-Cys1cpk Lgals3tm1Ftl MGI:3789178
cx5
Cys1cpk/Cys1cpk
Lgals3tm1Ftl/Lgals3tm1Ftl
involves: 129/Sv * C57BL/6 MGI:3789176


Genotype
MGI:3629701
hm1
Allelic
Composition
Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic
Background
B6.129S2-Lgals3tm1Ftl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Ftl mutation (2 available); any Lgals3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mild leukocytic infiltration is seen in the small intestine compared to wild-type 6 days after infection
• on days 14 and 28 there are many fewer infiltrating macrophages in the brain compared to controls
• there is a reduction in CD8 T cells in the brain on day 28 compared to controls
• mutants show a higher IgG2a to IgG1 ratio than controls
• after infection with T. gondii, mutant dendritic cells produces excess Il12p40
• levels are higher in mutant sera after infection
• levels of Ifng released from mutant splenocytes are higher up to day 14
• levels of Il12p40 are higher in mutant sera after infection
• higher amounts of Il12p40 are released by Lgals-deficient splenocytes even without stimulation
• inflammation seen in mutant brains is lower than in controls during the first 21 days of oral infection but by day 28, inflammation is comparable with that in controls
• after intraperitoneal infection, brains of mutants show 5-fold higher numbers of cysts compared to controls
• after initial 2 weeks post-infection, inflammation decreased in controls but persisted in mutant mice
• 4 days after intraperitoneal infection, mutants show a lower incidence of infiltrates containing neutrophils and macrophages
• in Lgals-deficient mice, no necrotic lesions of the villi in the small intestine are seen unlike in wild-type controls 8 days after oral infection; more pulmonary infiltrates are seen on day 21 in mutants
• parasitic burden in lungs of null mice is much higher than in controls on day7 after oral infection; tissue parasitism is higher in nulls on day14, but sharply declines on day 21
• in brains of null mice on day14, number of cysts in 11x higher than in controls after oral infection; this decreased to 6x on day 21 and 3x on day28
• Lgals-deficient mice show lower survival rates when infected intraperitoneally with T. gondii

hematopoietic system
• on days 14 and 28 there are many fewer infiltrating macrophages in the brain compared to controls
• there is a reduction in CD8 T cells in the brain on day 28 compared to controls
• mutants show a higher IgG2a to IgG1 ratio than controls

nervous system
• inflammation seen in mutant brains is lower than in controls during the first 21 days of oral infection but by day 28, inflammation is comparable with that in controls
• after intraperitoneal infection, brains of mutants show 5-fold higher numbers of cysts compared to controls

digestive/alimentary system
• mild leukocytic infiltration is seen in the small intestine compared to wild-type 6 days after infection

respiratory system
• after initial 2 weeks post-infection, inflammation decreased in controls but persisted in mutant mice
• 4 days after intraperitoneal infection, mutants show a lower incidence of infiltrates containing neutrophils and macrophages




Genotype
MGI:3629708
hm2
Allelic
Composition
Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Ftl mutation (2 available); any Lgals3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Lgals-deficient mice display attenuated peritoneal inflammation compared to wild-type upon stimulation with thioglycollate broth administration
• mutants show a higher percentage of eosinophils on days 1, 2 and 4 after thioglycollate broth treatment
• null mice have lower numbers of lymphocytes on days 2 and 4 after treatment
• on day 1 after treatment mutants have a lower percentage of monocytes/macrophages
• leukocytes from mutants show weaker NF-kappa b binding activity upon stimulation with thioglycollate broth than wild-type controls
• peritoneal macrophages show decreased areas of adherence in culture compared to wild-type
• Lgals-deficient macrophages are more sensitive to apoptotic stimuli in culture

hematopoietic system
• mutants show a higher percentage of eosinophils on days 1, 2 and 4 after thioglycollate broth treatment
• null mice have lower numbers of lymphocytes on days 2 and 4 after treatment
• on day 1 after treatment mutants have a lower percentage of monocytes/macrophages
• leukocytes from mutants show weaker NF-kappa b binding activity upon stimulation with thioglycollate broth than wild-type controls
• peritoneal macrophages show decreased areas of adherence in culture compared to wild-type
• Lgals-deficient macrophages are more sensitive to apoptotic stimuli in culture

digestive/alimentary system
• Lgals-deficient mice display attenuated peritoneal inflammation compared to wild-type upon stimulation with thioglycollate broth administration

cellular
• Lgals-deficient macrophages are more sensitive to apoptotic stimuli in culture




Genotype
MGI:5637814
hm3
Allelic
Composition
Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic
Background
involves: 129S2/SvPas * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Ftl mutation (2 available); any Lgals3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• the liver weight per body weight ratio is increased at 6 months of age

liver/biliary system
• neutrophil aggregation in the liver lobules and lymphocyte-predominant lobular inflammation with or without portal inflammation are seen at varying degrees after 15 months of age
• necroinflammation worsens with age focal hepatic necrosis
• neutrophil infiltration, Mallory bodies, and megamitochondria are seen occasionally in 6 month old mice (J:116073)
• 40%, 50%, and 100% of mice exhibit dysplastic liver nodules of various sizes at 15, 20, and 25 months of age, respectively (J:221030)
• nodules have no capsule and exhibit increased cellularity with irregular hepatocellular arrangement and cellular atypia is frequently seen (J:221030)
• focal and/or spotty necrosis are seen occasionally in 6 month old mice (J:116073)
(J:221030)
• the liver weight per body weight ratio is increased at 6 months of age
• in 6 month old mice
• hepatocytes of 6 month old mice show ballooning degeneration and scattered lipogranuloma
• Mallory bodies are seen occasionally in 6 month old mice
• livers show mild to severe macrovesicular and microvesicular fatty change which is enhanced in the perivenular area at 6 months of age (J:116073)
• the macro- and micro-vacuoles of hepatocytes contain lipids at 6 months of age (J:116073)
• mice develop features similar to nonalcoholic fatty liver disease that progresses to nonalcoholic steatohepatitis (J:221030)
• the degree of steatosis decreases with age, fat vesicles accumulating in hepatocytes become smaller in size and the distribution diffused in the liver parenchyma (J:221030)
• 40%, 75%, and 100% of mice develop mild to moderate perivenular and pericellular fibrosis at 15, 20, and 25 months of age, respectively
• inner nodules showing thick trabecular arrangement and pseudoglandular pattern are indicative of moderately differentiated hepatocellular carcinoma

homeostasis/metabolism
• in 6 month old mice

cellular
• focal and/or spotty necrosis are seen occasionally in 6 month old mice (J:116073)
(J:221030)
• lipid peroxide levels are higher in the liver at 2 and 6 months of age, indicating oxidative stress

immune system
• neutrophil aggregation in the liver lobules and lymphocyte-predominant lobular inflammation with or without portal inflammation are seen at varying degrees after 15 months of age
• necroinflammation worsens with age focal hepatic necrosis

neoplasm
• inner nodules showing thick trabecular arrangement and pseudoglandular pattern are indicative of moderately differentiated hepatocellular carcinoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fatty liver disease DOID:9452 OMIM:228100
J:116073 , J:221030




Genotype
MGI:3789178
cx4
Allelic
Composition
Cys1cpk/Cys1cpk
Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic
Background
B6.Cg-Cys1cpk Lgals3tm1Ftl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cys1cpk mutation (1 available); any Cys1 mutation (3 available)
Lgals3tm1Ftl mutation (2 available); any Lgals3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice develop medullary and cortical cysts
• however, gross ciliary structure is normal
• mice develop more cortical cysts than in Cys1cpk homozygotes

renal/urinary system
• mice develop medullary and cortical cysts
• however, gross ciliary structure is normal
• mice develop more cortical cysts than in Cys1cpk homozygotes




Genotype
MGI:3789176
cx5
Allelic
Composition
Cys1cpk/Cys1cpk
Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cys1cpk mutation (1 available); any Cys1 mutation (3 available)
Lgals3tm1Ftl mutation (2 available); any Lgals3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice develop medullary and cortical cysts
• however, gross ciliary structure is normal
• mice develop more cortical cysts than in Cys1cpk homozygotes
• mice exhibit an increase in kidney weight and kidney weight to body weight ratio compared to in Lgals3tm1Poi homozygotes

renal/urinary system
• mice develop medullary and cortical cysts
• however, gross ciliary structure is normal
• mice develop more cortical cysts than in Cys1cpk homozygotes
• mice exhibit an increase in kidney weight and kidney weight to body weight ratio compared to in Lgals3tm1Poi homozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory