Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafgtm1Jeng mutation
(0 available);
any
Mafg mutation
(38 available)
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mortality/aging
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• Background Sensitivity: lower than expected numbers of homozygotes born but not significantly
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hematopoietic system
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• three fold increase in megakaryocytes in both bone marrow and spleen
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• dramatically diminished platelet count
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behavior/neurological
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• Background Sensitivity: limb grasping behavior seen in mice on a C57BL/6 background after 5-6 months of age
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• Background Sensitivity: mice on a C57BL/6 background unable to grasp a wire with hind limbs
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growth/size/body
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• homozygous females weighed less than control littermates
• weight discrepancies less among males
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cellular
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• three fold increase in megakaryocytes in both bone marrow and spleen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafgtm1Jeng mutation
(0 available);
any
Mafg mutation
(38 available)
|
|
|
mortality/aging
|
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• Background Sensitivity: significantly lower than expected numbers of homozygotes born
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hematopoietic system
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• three fold increase in megakaryocytes in both bone marrow and spleen
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• dramatically diminished platelet count
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growth/size/body
|
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• homozygous females weighed less than control littermates
• weight discrepancies less among males
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cellular
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• three fold increase in megakaryocytes in both bone marrow and spleen
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafgtm1Jeng mutation
(0 available);
any
Mafg mutation
(38 available)
Mafktm1Jeng mutation
(0 available);
any
Mafk mutation
(13 available)
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hematopoietic system
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• large, mature megakaryocytes found
• failed to form proplatelets
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• platelets reduced to near zero
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behavior/neurological
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• limb grasping behavior develops by 6 weeks in about half of mice
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• motor activity repressed by auditory stimuli
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• intermittent but long lasting myoclonus in hind limbs of about 2/3 of mice, fully penetrant at 9 weeks of age
• occurs spontaneously but can be triggered by external stimuli such as eating or approaching table edge during free locomotion
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nervous system
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• intermittent but long lasting myoclonus in hind limbs of about 2/3 of mice, fully penetrant at 9 weeks of age
• occurs spontaneously but can be triggered by external stimuli such as eating or approaching table edge during free locomotion
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• neuronal nuclei in the gray matter of the spinal cord are swollen and the cytoplasm was thin
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muscle
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• intermittent but long lasting myoclonus in hind limbs of about 2/3 of mice, fully penetrant at 9 weeks of age
• occurs spontaneously but can be triggered by external stimuli such as eating or approaching table edge during free locomotion
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cellular
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• large, mature megakaryocytes found
• failed to form proplatelets
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafgtm1Jeng mutation
(0 available);
any
Mafg mutation
(38 available)
Mafktm1Jeng mutation
(0 available);
any
Mafk mutation
(13 available)
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mortality/aging
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• homozygotes born at considerably reduced numbers
• expected numbers of homozygous embryos at E18.5
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• did not survive to weaning
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hematopoietic system
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• persistent fetal liver hematopoiesis
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• often small, round and with irregular shapes
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• platelets reduced to near zero
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• reticulocyte numbers increased
• irregular reticulocyte morphology
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• red blood cells are less stable osmotically
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behavior/neurological
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• limb grasping behavior seen by 3-4 weeks of age
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• severe motor ataxia by 2 months of age
• intermittently spastic hind legs
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growth/size/body
immune system
Analysis Tools