Mouse Genome Informatics
hm1
    Abcc8tm1Jbry/Abcc8tm1Jbry
involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero

homeostasis/metabolism
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero
• significantly lower glucose levels after 16 hours of fasting
• elevated glucose at both 30 and 60 minutes after glucose injection


Mouse Genome Informatics
hm2
    Abcc8tm1Jbry/Abcc8tm1Jbry
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• hypoglycemic after 16 hour fast
• transient hypoglycemia at birth, reversed by day 2
• mild glucose intolerance in glucose tolerance tests


Mouse Genome Informatics
cx3
    Abcc8tm1Jbry/Abcc8tm1Jbry
Sstr5tm1Fcb/Sstr5tm1Fcb

involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero

homeostasis/metabolism
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero
• significantly lower glucose levels after 16 hours of fasting compared to wild type controls
• basal levels are like wild type controls
• very significantly elevated glucose at both 30 and 60 minutes after glucose injection