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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcc8tm1Jbry
targeted mutation 1, Joseph Bryan
MGI:2386677
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abcc8tm1Jbry/Abcc8tm1Jbry involves: 129X1/SvJ MGI:5303087
hm2
Abcc8tm1Jbry/Abcc8tm1Jbry involves: 129X1/SvJ * C57BL/6 MGI:2446456
cx3
Abcc8tm1Jbry/Abcc8tm1Jbry
Sstr5tm1Fcb/Sstr5tm1Fcb
involves: 129X1/SvJ MGI:5303086


Genotype
MGI:5303087
hm1
Allelic
Composition
Abcc8tm1Jbry/Abcc8tm1Jbry
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc8tm1Jbry mutation (0 available); any Abcc8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero

homeostasis/metabolism
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero
• significantly lower glucose levels after 16 hours of fasting
• elevated glucose at both 30 and 60 minutes after glucose injection




Genotype
MGI:2446456
hm2
Allelic
Composition
Abcc8tm1Jbry/Abcc8tm1Jbry
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc8tm1Jbry mutation (0 available); any Abcc8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• hypoglycemic after 16 hour fast
• transient hypoglycemia at birth, reversed by day 2
• mild glucose intolerance in glucose tolerance tests




Genotype
MGI:5303086
cx3
Allelic
Composition
Abcc8tm1Jbry/Abcc8tm1Jbry
Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc8tm1Jbry mutation (0 available); any Abcc8 mutation (24 available)
Sstr5tm1Fcb mutation (0 available); any Sstr5 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero

homeostasis/metabolism
• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls
• insulin levels near zero
• significantly lower glucose levels after 16 hours of fasting compared to wild type controls
• basal levels are like wild type controls
• very significantly elevated glucose at both 30 and 60 minutes after glucose injection





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory