Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax5tm3Mbu mutation
(1 available);
any
Pax5 mutation
(35 available)
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normal phenotype
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• mice were indistinguishable from wild-type mice
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immune system
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• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells
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• IgG class switching is decreased
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• short-lived IgM-B220lo and IgM+B220lo immature B cells are slightly lower in number
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• there is a 3-fold reduction in the number of long-lived mature B cells
• mice lack recirculating IgM+IgD+B220hi cells in the bone marrow
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• short-lived IgM-B220lo B cells are slightly lower in number
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• total immunoglobin is reduced 3-fold compared to control mice
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• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels
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hematopoietic system
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• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells
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• IgG class switching is decreased
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• short-lived IgM-B220lo and IgM+B220lo immature B cells are slightly lower in number
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• there is a 3-fold reduction in the number of long-lived mature B cells
• mice lack recirculating IgM+IgD+B220hi cells in the bone marrow
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• short-lived IgM-B220lo B cells are slightly lower in number
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• total immunoglobin is reduced 3-fold compared to control mice
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• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels
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immune system
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• half of the mature B cells in the spleen are absent
• only a small number of mature B cells are lost upon short-term inactivation of Pax5
• polyinosine-polycystosine (pIpC)-treated mice lack IgD+B220hi cells
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hematopoietic system
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• half of the mature B cells in the spleen are absent
• only a small number of mature B cells are lost upon short-term inactivation of Pax5
• polyinosine-polycystosine (pIpC)-treated mice lack IgD+B220hi cells
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neoplasm
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• mice exhibit increased penetrance and accelerated acute leukemia development compared to single Tcf3tm1(PBX1)Mlc conditional mutants
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hematopoietic system
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• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation
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• preleukemic mice show expansion of GFP+ progenitor cells of the Lin-CD19+CD43+ fractions at younger ages compared to single Tcf3tm1(PBX1)Mlc conditional mutants, indicating accelerated preleukemic progenitor B cell expansion
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• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation
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immune system
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• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation
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• preleukemic mice show expansion of GFP+ progenitor cells of the Lin-CD19+CD43+ fractions at younger ages compared to single Tcf3tm1(PBX1)Mlc conditional mutants, indicating accelerated preleukemic progenitor B cell expansion
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• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax5tm3Mbu mutation
(1 available);
any
Pax5 mutation
(35 available)
Tg(Gad1-cre,-lacZ)1Mini mutation
(0 available)
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mortality/aging
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• mice die 1-2 weeks after macroscopic changes appear (ie. domed skulls); life expectancy of such mutants is 58 days; mice that do not show this phenotype survive at least 12 months and are fertile
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skeleton
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• 47% of mice show dome shaped skulls by about postnatal day 50
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craniofacial
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• 47% of mice show dome shaped skulls by about postnatal day 50
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behavior/neurological
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• mutants spend less time in the center in open-field tests, suggesting increased anxiogenic-like behavior
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• in a novel open-field test, mutants with dome-shaped heads show significantly increased locomotion (likely due to the novelty aspect), as mutants appear lethargic in the home cages
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nervous system
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• prominent, varying mild to severe
• in most severe cases, medial structures between ventricles are deformed and compressed, as represented by vertically relocated hippocampi
• ventricular dilation might be result of obstruction of interventricular connections, increased CSF production by ependymal cells of the choroid plexus, or decreased CSF resorption by arachnoid villi
• other ventricles do not show enlargement
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• cortex surrounding lateral ventricles is markedly thinner than in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax5tm3Mbu mutation
(1 available);
any
Pax5 mutation
(35 available)
Tg(Gad1-cre,-lacZ)1Mini mutation
(0 available)
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mortality/aging
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• mice die 1-2 weeks after macroscopic changes appear (ie. domed skulls); life expectancy of such mutants is 58 days; mice that do not show this phenotype survive at least 12 months and are fertile
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skeleton
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• 19% of mice show dome shaped skulls by about postnatal day 50
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craniofacial
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• 19% of mice show dome shaped skulls by about postnatal day 50
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behavior/neurological
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• mutants spend less time in the center in open-field tests, suggesting increased anxiogenic-like behavior
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• in a novel open-field test, mutants with dome-shaped heads show significantly increased locomotion (likely due to the novelty aspect), as mutants appear lethargic in the home cages
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nervous system
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• prominent, varying mild to severe
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Analysis Tools
