Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.2Mhz mutation
(1 available);
any
Igf1r mutation
(86 available)
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mortality/aging
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• at birth mice cannot breath and die within the first few minutes of life
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respiratory system
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• at birth mice cannot breath
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growth/size/body
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• mice are 50.3% of wild-type weight
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muscle
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• mice exhibit general hypotrophia with particularly underdeveloped intercostals muscles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.2Mhz mutation
(1 available);
any
Igf1r mutation
(86 available)
Zfand2btm1Otin mutation
(0 available);
any
Zfand2b mutation
(11 available)
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hematopoietic system
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N |
• mice exhibit normal spleen weight with no significant alterations in hematocrit and WBC, lymphocyte, granulocyte or platelet number in peripheral blood relative to wild-type or single Igf1rtm1.2Mhz heterozygous controls at 6 and 12 months of age
• normal % and absolute number of LSK+ cells in bone marrow and spleen with no evidence of reticulin fibers (myelofibrosis) in bone marrow at 12 months of age, unlike in Zfand2btm1Otin homozygotes
• normal total number of bone marrow cells, with no significant differences in the number of mature myeloid cells or nucleated red cells relative to wild-type or single Igf1rtm1.2Mhz heterozygous controls
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neoplasm
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N |
• mice do NOT develop myeloproliferative neoplasms, unlike Zfand2btm1Otin homozygotes
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Analysis Tools