Phenotypes associated with this allele

• Allele Symbol: Slpi^tm1Smw
• Allele Name: targeted mutation 1, Sharon M Wahl
• Allele ID: MGI:2386293
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slpi^tm1Smw/Slpi^tm1Smw	involves: 129S1/Sv * 129X1/SvJ	MGI:3844968
hm2	Slpi^tm1Smw/Slpi^tm1Smw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3844937

Genotype
MGI:3844968

hm1

• Allelic Composition: Slpi^tm1Smw/Slpi^tm1Smw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet physiology ( J:95293 )

• activated platelets are unable to inhibit neutrophil elastase activity

homeostasis/metabolism

abnormal platelet physiology ( J:95293 )

• activated platelets are unable to inhibit neutrophil elastase activity

Genotype
MGI:3844937

hm2

• Allelic Composition: Slpi^tm1Smw/Slpi^tm1Smw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

homeostasis/metabolism

increased transforming growth factor beta level ( J:65241 )

• increased levels of the active form of TGF-beta are found in wound areas

• non-stimulated macrophages produce significantly more of the active form of TGF-beta than controls

abnormal wound healing ( J:65241 )

• there are increased numbers of neutrophils and monocytes associated with skin wounds within the first 24 hours of injury

delayed wound healing ( J:65241 )

• healing of full thickness dorsal incisions is significantly delayed in these mice

• wounds are still open 14 days after injury compared to wild-type mice that close their wounds within three days

• wound size is 9-fold greater 14 days after injury compared to controls

impaired wound healing ( J:65241 )

• collagen matrix deposition associated with full thickness dorsal incisions is impaired

• reduced matrix deposition may be associated with the increased elastase activity that occurs in mutant wounds