All Phenotypes Trp53<tm1Glo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm1Glo
targeted mutation 1, Guillermina Lozano
MGI:2386273

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Glo/Trp53^tm1Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:3814408
hm2	Trp53^tm1Glo/Trp53^tm1Glo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5003354
ht3	Trp53^tm1Glo/Trp53⁺	involves: 129S7/SvEvBrd	MGI:3814437
ht4	Trp53^tm1Glo/Trp53⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3814412
ht5	Trp53^tm1Glo/Trp53⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5003355
ht6	Trp53^tm1Glo/Trp53^tm4Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000505
cn7	Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:5000506
cx8	Cops6^{Gt(RRI087)Byg}/Cops6⁺ Trp53^tm1Glo/Trp53⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5003356
cx9	Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} Trp53^tm1Glo/Trp53^tm1Glo	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5003353
cx10	Kras^tm2Tyj/Kras⁺ Trp53^tm1Glo/Trp53⁺	involves: 129S2/SvPas * 129S7/SvEvBrd	MGI:3814436
cx11	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Glo/Trp53^tm1Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000503
cx12	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Glo/Trp53^tm4Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000502

Allelic Composition	Trp53^tm1Glo/Trp53^tm1Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:61683 )

• mice die by 40 weeks of age associated with early onset spontaneous tumor formation

neoplasm

increased tumor incidence ( J:61683 )

increased T cell derived lymphoma incidence ( J:61683 )

• in 75% of mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:61683 )

• in 75% of mice

Allelic Composition	Trp53^tm1Glo/Trp53^tm1Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

hematopoietic system

decreased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

cellular

decreased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

Allelic Composition	Trp53^tm1Glo/Trp53⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:129627 )

• mice develop adenocarcinomas, adenomas, lymphomas, osteosarcoma, and squamous carcinomas

increased lymphoma incidence ( J:129627 )

increased carcinoma incidence ( J:129627 )

• including lung adenocarcinomas

increased squamous cell carcinoma incidence ( J:129627 )

increased sarcoma incidence ( J:129627 )

increased osteosarcoma incidence ( J:129627 )

skeleton

increased osteosarcoma incidence ( J:129627 )

Allelic Composition	Trp53^tm1Glo/Trp53⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:61683 )

• premature death is associated with early onset spontaneous tumor formation

neoplasm

increased metastatic potential ( J:61683 )

• mice develop highly metastatic tumors such as osteosarcomas and carcinomas with 17 of 51 mice exhibiting metastasis nodules in the lung, liver or both

• 69% of osteosarcomas metastasize whereas osteosarcomas in mice heterozygous for a Trp53 null allele rarely metastasize

• 40% of adenocarcinomas and squamous cell carcinomas metastasize

• however, fibrosarcomas do not exhibit metastasis

increased tumor incidence ( J:61683 )

• mice exhibit an increased rate of tumorigenesis and develop osteosarcomas, fibrosarcomas, angiosarcomas, lyposarcomas, adenocarcinomas, hepatocellular carcinomas, poorly differentiated carcinomas, squamous cell carcinomas, lymphoma and adenoma

• however, tumorigenesis is rarely accompanied by loss of heterozygosity

increased lymphoma incidence ( J:61683 )

• 16% of mice develop lymphomas compared to 25% and 32% of mice heterozygous for one of two Trp53 null allele

increased carcinoma incidence ( J:61683 )

• 29% of mice develop carcinomas compared to only 10% of mice heterozygous for a Trp53 null allele

increased squamous cell carcinoma incidence ( J:61683 )

increased sarcoma incidence ( J:61683 )

• in 54% of mice

increased fibrosarcoma incidence ( J:61683 )

increased hemangiosarcoma incidence ( J:61683 )

increased osteosarcoma incidence ( J:61683 )

skeleton

increased osteosarcoma incidence ( J:61683 )

Allelic Composition	Trp53^tm1Glo/Trp53⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:172038 )

Allelic Composition	Trp53^tm1Glo/Trp53^tm4Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:171821 )

• medial survival is 251 days due to tumor development

neoplasm

abnormal tumor morphology ( J:171821 )

• tumors exhibit interstitial inflammatory cells unlike in tumors from Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

increased lipoma incidence ( J:171821 )

• in 2% of mice

increased lymphoma incidence ( J:171821 )

• in 34% of mice (including T cell, diffuse, anaplastic, and lymph node)

increased T cell derived lymphoma incidence ( J:171821 )

increased adenocarcinoma incidence ( J:171821 )

• in 2% of mice

increased spindle cell carcinoma incidence ( J:171821 )

increased sarcoma incidence ( J:171821 )

• in 61% of mice (including angiosarcoma, spindle-cell, giant-cell, and anaplastic)

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:171821 )

Allelic Composition	Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:171821 )

• tamoxifen-treated mice survive longer than Trp53^tm1Glo/Trp53^tm4Glo mice

neoplasm

abnormal tumor pathology ( J:171821 )

• tamoxifen-treated lymphomas exhibit decreased apoptosis response compared with tumors from Trp53^tm3.1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

• tamoxifen-treated tumors exhibit decreased cell proliferation compared with control samples

• angiosarcomas treated with tamoxifen exhibit increased senescence compared with tamoxifen-treated angiosarcomas from Trp53^tm3.1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

• tamoxifen-treatment induces apoptosis and senescence in giant-cell sarcoma

tumor regression ( J:171821 )

• in tamoxifen-treated mice

Allelic Composition	Cops6^{Gt(RRI087)Byg}/Cops6⁺ Trp53^tm1Glo/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops6^{Gt(RRI087)Byg} mutation (0 available); any Cops6 mutation (15 available)
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:172038 )

• mice exhibit a spectrum of gamma-irradiation-induced tumors intermediate to in Trp53^tm1Glo heterozygotes and Cops6^{Gt(RRI087)Byg} heterozygotes

Allelic Composition	Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} Trp53^tm1Glo/Trp53^tm1Glo
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The embryonic lethality of Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} mice can be partially rescued by concomitant loss of Trp53

mortality/aging

prenatal lethality, complete penetrance ( J:172038 )

• no mice are detected at birth

• however, mice were identified at E8.5 to E10.5 indicating a partial rescue

embryo

embryonic growth retardation ( J:172038 )

• at E9.5

decreased embryo size ( J:172038 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:172038 )

• at E9.5

decreased embryo size ( J:172038 )

• at E9.5

Allelic Composition	Kras^tm2Tyj/Kras⁺ Trp53^tm1Glo/Trp53⁺
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm2Tyj mutation (1 available); any Kras mutation (76 available)
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:129627 )

• average lifespan is 266 days with female mice exhibiting shorter lifespans than male mice

neoplasm

increased metastatic potential ( J:129627 )

• lung adenocarcinomas and mesothelioma are highly invasive and metastatic with metastatic lesions observed in the lymph nodes and liver

• 19 of 52 mice with lung adenocarcinomas exhibit metastasis compared to only 2 of 44 Kras^tm2Tyj heterozygotes

abnormal tumor morphology ( J:129627 )

• 81.8% of mice with end-stage lung adenocarcinomas exhibit loss of heterozygosity of the Trp53 wild-type allele

increased tumor incidence ( J:129627 )

• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, pancreatic carcinomas, squamous carcinomas, and papillomas

increased lung adenoma incidence ( J:129627 )

• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas

• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated

increased lymphoma incidence ( J:129627 )

• some mice develop lung lymphomas

increased squamous cell carcinoma incidence ( J:129627 )

increased fibrosarcoma incidence ( J:129627 )

increased hemangiosarcoma incidence ( J:129627 )

increased mesothelioma incidence ( J:129627 )

• 13 of 56 mice develop mesothelioma 6 of which are peritoneal mesotheliomas

increased papilloma incidence ( J:129627 )

respiratory system

increased lung adenoma incidence ( J:129627 )

• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas

• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:129627

Allelic Composition	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Glo/Trp53^tm1Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:171821 )

• as in Mdm2^tm1Glo homozygotes

Allelic Composition	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Glo/Trp53^tm4Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:171821 )

growth/size/body

decreased body size ( J:171821 )

behavior/neurological

decreased locomotor activity ( J:171821 )

• less mobile

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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