Phenotypes associated with this allele

• Allele Symbol: C3^tm1Pkna
• Allele Name: targeted mutation 1, Marcela Pekna
• Allele ID: MGI:2386266
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C3^tm1Pkna/C3^tm1Pkna	D1.129P2-C3^tm1Pkna	MGI:3040867
hm2	C3^tm1Pkna/C3^tm1Pkna	involves: 129P2/OlaHsd * C57BL/6	MGI:2449062

Genotype
MGI:3040867

hm1

• Allelic Composition: C3^tm1Pkna/C3^tm1Pkna
• Genetic Background: D1.129P2-C3^tm1Pkna

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to induced arthritis ( J:88872 )

• reduced penetrance of induced arthritis, with only 75% of mice developing inflammation

• reduced severity of induced arthritis relative to control mice

• delayed onset of induced arthritis relative to control mice

skeleton

decreased susceptibility to induced arthritis ( J:88872 )

• reduced penetrance of induced arthritis, with only 75% of mice developing inflammation

• reduced severity of induced arthritis relative to control mice

• delayed onset of induced arthritis relative to control mice

Genotype
MGI:2449062

hm2

• Allelic Composition: C3^tm1Pkna/C3^tm1Pkna
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:45857 )

• mice on a mixed genetic background involving 129P2/OlaHsd and C57BL/6 are born at a normal Mendelian ratio and develop normally in a conventional mouse facility

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
complement component 3 deficiency		DOID:8354	OMIM:613779	J:45857