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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pdcd1tm1Hon
targeted mutation 1, Tasuku Honjo
MGI:2386184
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pdcd1tm1Hon/Pdcd1tm1Hon B6.129S2-Pdcd1tm1Hon MGI:3054644
hm2
Pdcd1tm1Hon/Pdcd1tm1Hon BALB/c MGI:3054645
hm3
Pdcd1tm1Hon/Pdcd1tm1Hon involves: 129S2/SvPas MGI:5770299
hm4
Pdcd1tm1Hon/Pdcd1tm1Hon involves: 129S2/SvPas * C57BL/6 MGI:3054643
cx5
Btlatm1Kmm/Btlatm1Kmm
Pdcd1tm1Hon/Pdcd1tm1Hon
B6.129S-Pdcd1tm1Hon Btlatm1Kmm MGI:3706173
cx6
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas MGI:3814894
cx7
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129S2/SvPas * 129S4/SvJae * BALB/c MGI:5574062
cx8
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 MGI:5770302
cx9
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 MGI:5770303


Genotype
MGI:3054644
hm1
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
B6.129S2-Pdcd1tm1Hon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased layers of synovial tissues in foot joints at 6 months of age
• arthritic lesions more pronounced at 14 months of age
• mild proliferative glomerulonephritis at 6 months age
• less than 50% of glomeruli affected
• by 14 months, 50% of mice with a lupus-like glomerulonephritis
• only about 80% of mice show long term MHC class II mismatch allograft survival (Bm12 into B6) compared to about 100% survival in wild-type mice
• however, survival time of MHC class I mismatch allografts is the same as wild-type controls

renal/urinary system
• mild proliferative glomerulonephritis at 6 months age
• less than 50% of glomeruli affected
• by 14 months, 50% of mice with a lupus-like glomerulonephritis

skeleton
• increased layers of synovial tissues in foot joints at 6 months of age
• arthritic lesions more pronounced at 14 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:78802




Genotype
MGI:3054645
hm2
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• start to die around 5 weeks of age, 2/3 are dead by 30 weeks

cardiovascular system
• massively enlarged hearts at death
• thin right venricular wall
• both ventricles dilated to about 2X normal diameter
• sporatic fibrosis and scar formation
• impaired pump function of the heart
• reduced movement of the ventricular walls and interventricular septum

immune system
• higher titers of autoantibodies (IgG1)
• deposition of IgG and C3 complement around cardiomyocytes

liver/biliary system
• varying degrees of hepatomegaly

muscle
• reduced movement of the ventricular walls and interventricular septum

vision/eye
• protrusion of eyeballs occurs a few weeks before death

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:66979




Genotype
MGI:5770299
hm3
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells
• on in vitro restimulation of T cells
• when T cells are challenged with antigen
• increased leukocyte infiltration with tissue necrosis in several organs including lung, liver and pancreas

endocrine/exocrine glands

liver/biliary system

respiratory system

hematopoietic system
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells




Genotype
MGI:3054643
hm4
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• myeloid lineages in the spleen are also increased
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• moderate splenomegaly
• proliferative response of B cells to anti-IgM is greatly enhanced
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

immune system
• myeloid lineages in the spleen are also increased
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• moderate splenomegaly
• proliferative response of B cells to anti-IgM is greatly enhanced
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:50688




Genotype
MGI:3706173
cx5
Allelic
Composition
Btlatm1Kmm/Btlatm1Kmm
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
B6.129S-Pdcd1tm1Hon Btlatm1Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btlatm1Kmm mutation (3 available); any Btla mutation (9 available)
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in proliferation in response to fully MHC-mismatched stimulation
• increase is decreased by rapamycin treatment
• decreased survival time of cardiac allografts (source strain Bm12; 10.5 +/- 1.5 days) compared to mice homozygous for the Btla allele alone (14.3 +/- 3.8 days) or wild-type mice (over 100 days)

hematopoietic system
• increase in proliferation in response to fully MHC-mismatched stimulation
• increase is decreased by rapamycin treatment




Genotype
MGI:3814894
cx6
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in conjunction with anti-CTLA-4 antibody treatment, mice exhibit reduced paralysis induced by experimental autoimmune encephalomyelitis (EAE) compared to wild type mice
• however, adoptive transfer of Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells increases paralysis induced by EAE despite treatment with anti-CTLA-4 antibodies compared to wild-type mice receiving Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells




Genotype
MGI:5574062
cx7
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (22 available)
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies
• urinary cytokines, including, GM-CSF, TNF-alpha, IL1-alpha, G-CSF, IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies
• anti-urothelial autoantibodies are seen in the serum as early as 7 weeks of age, with about 50% of mice showing autoantibodies at 10 weeks of age
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer

renal/urinary system
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer
• mice that are positive for anti-urothelial antibodies show disarrangement of urothelial plaque on the surface of the bladder and disarranged cellular structure of the bladder epithelium at 16 weeks of age
• surface of bladder epithelium shows poorer plaque formation, exposing bare surface of smaller epithelial cells beneath it, in mice that are positive for anti-urothelial antibodies
• mice that are positive for anti-urothelial antibodies void less urine per void than wild-type mice, even when corrected for body weight

homeostasis/metabolism
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies
• urinary cytokines, including, GM-CSF, TNF-alpha, IL1-alpha, G-CSF, IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies

growth/size/body
• lower body weight in mice that are positive for anti-urothelial antibodies




Genotype
MGI:5770302
cx8
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Genetic
Background
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
Vsirtm1Lex mutation (3 available); any Vsir mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not develop overt autoimmune disease
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells
• on in vitro restimulation of T cells
• when T cells are challenged with antigen
• on in vitro restimulation of T cells
• on in vitro restimulation of T cells
• increased leukocyte infiltration with tissue necrosis in several organs including lung, liver and pancreas

endocrine/exocrine glands

liver/biliary system

respiratory system

hematopoietic system
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells




Genotype
MGI:5770303
cx9
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Vsirtm1Lex mutation (3 available); any Vsir mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit accelerated onset and succumb to complete hindlimb paralysis faster than control mice





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory