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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pdcd1tm1Hon
targeted mutation 1, Tasuku Honjo
MGI:2386184
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pdcd1tm1Hon/Pdcd1tm1Hon B6.129S2-Pdcd1tm1Hon MGI:3054644
hm2
Pdcd1tm1Hon/Pdcd1tm1Hon BALB/c MGI:3054645
hm3
Pdcd1tm1Hon/Pdcd1tm1Hon involves: 129S2/SvPas * C57BL/6 MGI:3054643
cx4
Btlatm1Kmm/Btlatm1Kmm
Pdcd1tm1Hon/Pdcd1tm1Hon
B6.129S-Pdcd1tm1Hon Btlatm1Kmm MGI:3706173
cx5
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas MGI:3814894
cx6
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129S2/SvPas * 129S4/SvJae * BALB/c MGI:5574062


Genotype
MGI:3054644
hm1
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
B6.129S2-Pdcd1tm1Hon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased layers of synovial tissues in foot joints at 6 months of age (J:78802)
• arthritic lesions more pronounced at 14 months of age (J:78802)
• increased layers of synovial tissues in foot joints at 6 months of age (J:78802)
• arthritic lesions more pronounced at 14 months of age (J:78802)
• mild proliferative glomerulonephritis at 6 months age (J:78802)
• less than 50% of glomeruli affected (J:78802)
• by 14 months, 50% of mice with a lupus-like glomerulonephritis (J:78802)
• mild proliferative glomerulonephritis at 6 months age (J:78802)
• less than 50% of glomeruli affected (J:78802)
• by 14 months, 50% of mice with a lupus-like glomerulonephritis (J:78802)
• only about 80% of mice show long term MHC class II mismatch allograft survival (Bm12 into B6) compared to about 100% survival in wild-type mice (J:119356)
• however, survival time of MHC class I mismatch allografts is the same as wild-type controls (J:119356)
• only about 80% of mice show long term MHC class II mismatch allograft survival (Bm12 into B6) compared to about 100% survival in wild-type mice (J:119356)
• however, survival time of MHC class I mismatch allografts is the same as wild-type controls (J:119356)

renal/urinary system
• mild proliferative glomerulonephritis at 6 months age (J:78802)
• less than 50% of glomeruli affected (J:78802)
• by 14 months, 50% of mice with a lupus-like glomerulonephritis (J:78802)
• mild proliferative glomerulonephritis at 6 months age (J:78802)
• less than 50% of glomeruli affected (J:78802)
• by 14 months, 50% of mice with a lupus-like glomerulonephritis (J:78802)

skeleton
• increased layers of synovial tissues in foot joints at 6 months of age (J:78802)
• arthritic lesions more pronounced at 14 months of age (J:78802)
• increased layers of synovial tissues in foot joints at 6 months of age (J:78802)
• arthritic lesions more pronounced at 14 months of age (J:78802)

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:78802




Genotype
MGI:3054645
hm2
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• start to die around 5 weeks of age, 2/3 are dead by 30 weeks (J:66979)
• start to die around 5 weeks of age, 2/3 are dead by 30 weeks (J:66979)

cardiovascular system
• massively enlarged hearts at death (J:66979)
• massively enlarged hearts at death (J:66979)
• thin right venricular wall (J:66979)
• thin right venricular wall (J:66979)
• both ventricles dilated to about 2X normal diameter (J:66979)
• both ventricles dilated to about 2X normal diameter (J:66979)
• sporatic fibrosis and scar formation (J:66979)
• sporatic fibrosis and scar formation (J:66979)
• impaired pump function of the heart (J:66979)
• impaired pump function of the heart (J:66979)
• reduced movement of the ventricular walls and interventricular septum (J:66979)
• reduced movement of the ventricular walls and interventricular septum (J:66979)

immune system
• higher titers of autoantibodies (IgG1) (J:66979)
• deposition of IgG and C3 complement around cardiomyocytes (J:66979)
• higher titers of autoantibodies (IgG1) (J:66979)
• deposition of IgG and C3 complement around cardiomyocytes (J:66979)

liver/biliary system
• varying degrees of hepatomegaly (J:66979)
• varying degrees of hepatomegaly (J:66979)

muscle
• reduced movement of the ventricular walls and interventricular septum (J:66979)
• reduced movement of the ventricular walls and interventricular septum (J:66979)

vision/eye
• protrusion of eyeballs occurs a few weeks before death (J:66979)
• protrusion of eyeballs occurs a few weeks before death (J:66979)

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:66979




Genotype
MGI:3054643
hm3
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• myeloid lineages in the spleen are also increased (J:50688)
• myeloid lineages in the spleen are also increased (J:50688)
• lymphoid cells in the peritoneal cavity increased about 2 fold (J:50688)
• lymphoid cells in the peritoneal cavity increased about 2 fold (J:50688)
• increased numbers of B cells in the spleen (J:50688)
• increased numbers of B cells in the spleen (J:50688)
• B1 cells in the peritoneal cavity are increased (J:50688)
• B1 cells in the peritoneal cavity are increased (J:50688)
• moderate splenomegaly (J:50688)
• moderate splenomegaly (J:50688)
• proliferative response of B cells to anti-IgM is greatly enhanced (J:50688)
• proliferative response of B cells to anti-IgM is greatly enhanced (J:50688)
• increased T cell independent antigen responses (J:50688)
• T cell dependent antigen responses were normal (J:50688)
• increased T cell independent antigen responses (J:50688)
• T cell dependent antigen responses were normal (J:50688)
• IgG2b levels were increased (J:50688)
• IgG2b levels were increased (J:50688)
• IgG3 levels were 3X normal (J:50688)
• IgG3 levels were 3X normal (J:50688)

immune system
• myeloid lineages in the spleen are also increased (J:50688)
• myeloid lineages in the spleen are also increased (J:50688)
• lymphoid cells in the peritoneal cavity increased about 2 fold (J:50688)
• lymphoid cells in the peritoneal cavity increased about 2 fold (J:50688)
• increased numbers of B cells in the spleen (J:50688)
• increased numbers of B cells in the spleen (J:50688)
• B1 cells in the peritoneal cavity are increased (J:50688)
• B1 cells in the peritoneal cavity are increased (J:50688)
• moderate splenomegaly (J:50688)
• moderate splenomegaly (J:50688)
• proliferative response of B cells to anti-IgM is greatly enhanced (J:50688)
• proliferative response of B cells to anti-IgM is greatly enhanced (J:50688)
• increased T cell independent antigen responses (J:50688)
• T cell dependent antigen responses were normal (J:50688)
• increased T cell independent antigen responses (J:50688)
• T cell dependent antigen responses were normal (J:50688)
• IgG2b levels were increased (J:50688)
• IgG2b levels were increased (J:50688)
• IgG3 levels were 3X normal (J:50688)
• IgG3 levels were 3X normal (J:50688)

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:50688




Genotype
MGI:3706173
cx4
Allelic
Composition
Btlatm1Kmm/Btlatm1Kmm
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
B6.129S-Pdcd1tm1Hon Btlatm1Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btlatm1Kmm mutation (3 available); any Btla mutation (6 available)
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in proliferation in response to fully MHC-mismatched stimulation (J:119356)
• increase is decreased by rapamycin treatment (J:119356)
• increase in proliferation in response to fully MHC-mismatched stimulation (J:119356)
• increase is decreased by rapamycin treatment (J:119356)
• decreased survival time of cardiac allografts (source strain Bm12; 10.5 +/- 1.5 days) compared to mice homozygous for the Btla allele alone (14.3 +/- 3.8 days) or wild-type mice (over 100 days) (J:119356)
• decreased survival time of cardiac allografts (source strain Bm12; 10.5 +/- 1.5 days) compared to mice homozygous for the Btla allele alone (14.3 +/- 3.8 days) or wild-type mice (over 100 days) (J:119356)

hematopoietic system
• increase in proliferation in response to fully MHC-mismatched stimulation (J:119356)
• increase is decreased by rapamycin treatment (J:119356)
• increase in proliferation in response to fully MHC-mismatched stimulation (J:119356)
• increase is decreased by rapamycin treatment (J:119356)




Genotype
MGI:3814894
cx5
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (13 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in conjunction with anti-CTLA-4 antibody treatment, mice exhibit reduced paralysis induced by experimental autoimmune encephalomyelitis (EAE) compared to wild type mice (J:140751)
• however, adoptive transfer of Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells increases paralysis induced by EAE despite treatment with anti-CTLA-4 antibodies compared to wild-type mice receiving Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells (J:140751)
• in conjunction with anti-CTLA-4 antibody treatment, mice exhibit reduced paralysis induced by experimental autoimmune encephalomyelitis (EAE) compared to wild type mice (J:140751)
• however, adoptive transfer of Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells increases paralysis induced by EAE despite treatment with anti-CTLA-4 antibodies compared to wild-type mice receiving Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells (J:140751)




Genotype
MGI:5574062
cx6
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (17 available)
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies (J:207275)
• urinary cytokines, including, GM-CSF, TNF-alpha, IL1-alpha, G-CSF, IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies (J:207275)
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies (J:207275)
• urinary cytokines, including, GM-CSF, TNF-alpha, IL1-alpha, G-CSF, IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies (J:207275)
• anti-urothelial autoantibodies are seen in the serum as early as 7 weeks of age, with about 50% of mice showing autoantibodies at 10 weeks of age (J:207275)
• anti-urothelial autoantibodies are seen in the serum as early as 7 weeks of age, with about 50% of mice showing autoantibodies at 10 weeks of age (J:207275)
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer (J:207275)
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer (J:207275)

renal/urinary system
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer (J:207275)
• mice that are positive for anti-urothelial antibodies show massive infiltration of inflammatory cells at the suburothelial layer (J:207275)
• mice that are positive for anti-urothelial antibodies show disarrangement of urothelial plaque on the surface of the bladder and disarranged cellular structure of the bladder epithelium at 16 weeks of age (J:207275)
• surface of bladder epithelium shows poorer plaque formation, exposing bare surface of smaller epithelial cells beneath it, in mice that are positive for anti-urothelial antibodies (J:207275)
• mice that are positive for anti-urothelial antibodies show disarrangement of urothelial plaque on the surface of the bladder and disarranged cellular structure of the bladder epithelium at 16 weeks of age (J:207275)
• surface of bladder epithelium shows poorer plaque formation, exposing bare surface of smaller epithelial cells beneath it, in mice that are positive for anti-urothelial antibodies (J:207275)
• mice that are positive for anti-urothelial antibodies void less urine per void than wild-type mice, even when corrected for body weight (J:207275)
• mice that are positive for anti-urothelial antibodies void less urine per void than wild-type mice, even when corrected for body weight (J:207275)

homeostasis/metabolism
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies (J:207275)
• urinary cytokines, including, GM-CSF, TNF-alpha, IL1-alpha, G-CSF, IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies (J:207275)
• inflammatory cytokines, including Il2ra, Tnf, Icos, Il1b, Socs1, and Vcam1, are expressed in the suburothelial layer of mice that have anti-urothelial antibodies (J:207275)
• urinary cytokines, including, GM-CSF, TNF-alpha, IL1-alpha, G-CSF, IL-1beta, are upregulated in the urine of mice that have anti-urothelial antibodies (J:207275)

growth/size/body
• lower body weight in mice that are positive for anti-urothelial antibodies (J:207275)
• lower body weight in mice that are positive for anti-urothelial antibodies (J:207275)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory