About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hrastm1Mok
targeted mutation 1, Moyota Katsuki
MGI:2386128
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hrastm1Mok/Hrastm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3036357
cx2
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok 		either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361202
cx3
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)7Mok/0 		either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361207
cx4
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok 		either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361200
cx5
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0 		involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821330
cx6
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0 		involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821332
cx7
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nras+ 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821328
cx8
 		Hrastm1Mok/Hras+
Nrastm1Mok/Nrastm1Mok 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821333
cx9
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+ 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821327
cx10
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821331
cx11
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+ 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821329


Genotype
MGI:3036357
hm1
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:62962 )
• a decreased susceptibility to DMBA induced skin papillomas was demonstrated
• no difference in spontaneous tumor formation was detected compared to wild-type mice

homeostasis/metabolism
chylous ascites ( J:159024 )
• 2 of 228 mice develop chylous ascites unlike wild-type mice
decreased incidence of tumors by chemical induction ( J:62962 )
• a decreased susceptibility to DMBA induced skin papillomas was demonstrated
• no difference in spontaneous tumor formation was detected compared to wild-type mice




Genotype
MGI:4361202
cx2
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:135610 )
• development is normal to E9.5
• most are dead by E11.5
• none are found at E13.5




Genotype
MGI:4361207
cx3
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)7Mok/0
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (76 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)7Mok mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:135610 )
• born in expected numbers




Genotype
MGI:4361200
cx4
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:135610 )
• born in reduced numbers




Genotype
MGI:4821330
cx5
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (76 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159024 )
N
• no mice exhibit chylous ascites




Genotype
MGI:4821332
cx6
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159024 )
N
• no mice exhibit chylous ascites




Genotype
MGI:4821328
cx7
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nras+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 2 of 175 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821333
cx8
Allelic
Composition		 Hrastm1Mok/Hras+
Nrastm1Mok/Nrastm1Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 5 of 153 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821327
cx9
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 20 of 135 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821331
cx10
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 64 of 137 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821329
cx11
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (76 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 35 of 37 mice develop chylous ascites unlike wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory