All Phenotypes Dmrt1<tm1.1Zark> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmrt1^tm1.1Zark/Dmrt1^tm1.1Zark	involves: 129 * C57BL/6	MGI:3703151
cn2	Alpl^tm1(cre)Nagy/Alpl⁺ Dmrt1^tm1Zark/Dmrt1^tm1.1Zark	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3851611
cn3	Dmrt1^tm1Zark/Dmrt1^tm1.1Zark Tg(Dhh-cre)1Mejr/0	involves: 129/Sv * C57BL/6	MGI:3851610

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased male germ cell number ( J:65541 )

• the number of germ cells in males is normal at postnatal day 7, greatly reduced by day 10 and absent by day 14

• no meiotic germ cells are evident

• by six weeks of age testes have no germ cells

increased Sertoli cell proliferation ( J:65541 )

• by 10 days of age, Sertoli cells over-proliferate and remain immature

reproductive system

decreased male germ cell number ( J:65541 )

• the number of germ cells in males is normal at postnatal day 7, greatly reduced by day 10 and absent by day 14

• no meiotic germ cells are evident

• by six weeks of age testes have no germ cells

abnormal seminiferous tubule morphology ( J:65541 )

• tubules lack lumen

• tubules are populated by immature Sertoli cells

abnormal Sertoli cell morphology ( J:65541 )

• cells overproliferate, fail to differentiate and die after the mouse is born

abnormal testis development ( J:65541 )

• defects resemble those in humans with distal 9p deletions

increased Sertoli cell proliferation ( J:65541 )

• by 10 days of age, Sertoli cells over-proliferate and remain immature

small testis ( J:65541 )

abnormal male meiosis ( J:65541 )

• germ cells do not enter meiosis

male infertility ( J:65541 )

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:65541 )

• tubules lack lumen

• tubules are populated by immature Sertoli cells

abnormal Sertoli cell morphology ( J:65541 )

• cells overproliferate, fail to differentiate and die after the mouse is born

abnormal testis development ( J:65541 )

• defects resemble those in humans with distal 9p deletions

increased Sertoli cell proliferation ( J:65541 )

• by 10 days of age, Sertoli cells over-proliferate and remain immature

small testis ( J:65541 )

Allelic Composition	Alpl^tm1(cre)Nagy/Alpl⁺ Dmrt1^tm1Zark/Dmrt1^tm1.1Zark
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^tm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Dmrt1^tm1.1Zark mutation (0 available); any Dmrt1 mutation (48 available)
Dmrt1^tm1Zark mutation (0 available); any Dmrt1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogonia morphology ( J:122954 )

• many germ cells fail to migrate to the periphery

decreased male germ cell number ( J:122954 )

• fewer germ cells indicating cells fail to reactivate mitosis

abnormal testis development ( J:122954 )

• many germ cells fail to migrate to the periphery

• however, Sertoli cells are normally polarized

endocrine/exocrine glands

abnormal testis development ( J:122954 )

• many germ cells fail to migrate to the periphery

• however, Sertoli cells are normally polarized

cellular

abnormal spermatogonia morphology ( J:122954 )

• many germ cells fail to migrate to the periphery

decreased male germ cell number ( J:122954 )

• fewer germ cells indicating cells fail to reactivate mitosis

Allelic Composition	Dmrt1^tm1Zark/Dmrt1^tm1.1Zark Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmrt1^tm1.1Zark mutation (0 available); any Dmrt1 mutation (48 available)
Dmrt1^tm1Zark mutation (0 available); any Dmrt1 mutation (48 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal testis development ( J:122954 )

• at P9 Sertoli cells are randomly distributed unlike in controls

• at P14 tubules lack luminal space and are instead filled with a poorly organized mix of Sertoli cells and differentiating germ cells

• at P28 tubules contain no apparent germ cells and are filled with randomized, unpolarized Sertoli cells with immature morphology

abnormal Sertoli cell development ( J:122954 )

• Sertoli cells fail to migrate properly and retain an immature morphology at P28

reproductive system

abnormal spermatogonia morphology ( J:122954 )

• by P9 the distribution of germs cells is highly abnormal with more cells in the center and fewer cells at the periphery of the tubules

• meiosis initiates but germ cells are absent by P28

abnormal testis development ( J:122954 )

• at P9 Sertoli cells are randomly distributed unlike in controls

• at P14 tubules lack luminal space and are instead filled with a poorly organized mix of Sertoli cells and differentiating germ cells

• at P28 tubules contain no apparent germ cells and are filled with randomized, unpolarized Sertoli cells with immature morphology

abnormal Sertoli cell development ( J:122954 )

• Sertoli cells fail to migrate properly and retain an immature morphology at P28

cellular

abnormal spermatogonia morphology ( J:122954 )

• by P9 the distribution of germs cells is highly abnormal with more cells in the center and fewer cells at the periphery of the tubules

• meiosis initiates but germ cells are absent by P28

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