Mouse Genome Informatics
tg1
    Tg(Cyp19)C2-3Rrte/0
involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• infertile males have enlarged testes (J:60034)
• about 50% of males at 6 - 12 months of age are infertile (J:60034)

tumorigenesis
• about 25 % of virgin transgenic females exposed to 0.5 ug of DMBA at 56 days of age develop palpable low-grade mammary tumors and all DMBA exposed transgenic females have microscopic evidence of mammary tumor formation or neoplastic progression unlike wild type females
• about 15% of enlarged ducts in virgin females are fibroadenomas
• about 5-10% of hyperplastic ducts in females after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution appear similar to fibroadenomas

homeostasis/metabolism
• transgenic males have significantly increased serum estradiol levels compared to wild-type males
• about 25 % of virgin transgenic females exposed to 0.5 ug of DMBA at 56 days of age develop palpable low-grade mammary tumors and all DMBA exposed transgenic females have microscopic evidence of mammary tumor formation or neoplastic progression unlike wild type females

endocrine/exocrine glands
• in virgin females 40% of ducts are enlarged and 65% of these have hyperplastic lesions while 20% have dysplatic lesions (J:34063)
• after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with numerous terminal ducts seen, in addition 15% show ductal and lobular dysplasia (J:34063)
• ductal hyperplasia is still evident after 5 months of involution (J:34063)
• after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with abundant alveolar glands seen, in addition 15% show ductal and lobular dysplasia (J:34063)
• transgenic males display mammary hyperplasia and dysplasia by as early as 3 months of age (J:78693)
• infertile males have enlarged testes (J:60034)

integument
• in virgin females 40% of ducts are enlarged and 65% of these have hyperplastic lesions while 20% have dysplatic lesions (J:34063)
• after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with numerous terminal ducts seen, in addition 15% show ductal and lobular dysplasia (J:34063)
• ductal hyperplasia is still evident after 5 months of involution (J:34063)
• after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with abundant alveolar glands seen, in addition 15% show ductal and lobular dysplasia (J:34063)
• transgenic males display mammary hyperplasia and dysplasia by as early as 3 months of age (J:78693)

Mouse Models of Human Disease
OMIM IDRef(s)
Aromatase Excess Syndrome; AEXS 139300 J:78693