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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ins2-Fasl)24Ach
transgene insertion 24, Alexander V Chervonsky
MGI:2385760
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0
NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach MGI:3663041
cx2
Prkdcscid/Prkdcscid
Tg(Ins2-Fasl)24Ach/0
NOD.CB17-Prkdcscid Tg(Ins2-Fasl)24Ach MGI:3663017
cx3
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0
NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach MGI:3663021
tg4
Tg(Ins2-Fasl)24Ach/0 NOD-Tg(Ins2-Fasl)24Ach/J MGI:3581611


Genotype
MGI:3663041
cx1
Allelic
Composition
Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0
Genetic
Background
NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fas*I246N)1Ach mutation (1 available)
Tg(Ins2-Fasl)24Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• double transgenics show slower onset of diabetes compared to NOD-Tg(Ins2-Fasl)24Ach single transgenics

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81416




Genotype
MGI:3663017
cx2
Allelic
Composition
Prkdcscid/Prkdcscid
Tg(Ins2-Fasl)24Ach/0
Genetic
Background
NOD.CB17-Prkdcscid Tg(Ins2-Fasl)24Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (72 available); any Prkdc mutation (188 available)
Tg(Ins2-Fasl)24Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• female mice do not develop spontaneous diabetes assessed by monitoring urine glucose levels observed for >30 weeks
• 6/6 mice show accelerated diabetes development determined by urine glucose level monitoring, showing the disease by ~14 days of transfer of splenocytes from diabetic NOD mice




Genotype
MGI:3663021
cx3
Allelic
Composition
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0
Genetic
Background
NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (24 available); any Fas mutation (54 available)
Tg(Ins2-Fasl)24Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when mice are injected with islet-specific CD8+ T cells, 0/5 transgenic Fas-deficient mice become diabetic whereas 5/5 transgenic Fas-sufficient mice develop diabetes 5 days after transfer

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81416




Genotype
MGI:3581611
tg4
Allelic
Composition
Tg(Ins2-Fasl)24Ach/0
Genetic
Background
NOD-Tg(Ins2-Fasl)24Ach/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fasl)24Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• majority of mice develop diabetes by 10 weeks of age vs controls which develop diabetes by 12 weeks of age; diabetes determined as blood glucose greater than 250 mg/dl (J:78679)
• mice develop diabetes in ~ 5 days of transfer of diabetogenic T cells (J:81416)

endocrine/exocrine glands
• at 25 weeks of age, transgenic mice show significant islet damage with little remaining insulin

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:78679





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory