Mouse Genome Informatics
cx1
    Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0

NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• double transgenics show slower onset of diabetes compared to NOD-Tg(Ins2-Fasl)24Ach single transgenics

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81416


Mouse Genome Informatics
cx2
    Prkdcscid/Prkdcscid
Tg(Ins2-Fasl)24Ach/0

NOD.CB17-Prkdcscid Tg(Ins2-Fasl)24Ach
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• female mice do not develop spontaneous diabetes assessed by monitoring urine glucose levels observed for >30 weeks
• 6/6 mice show accelerated diabetes development determined by urine glucose level monitoring, showing the disease by ~14 days of transfer of splenocytes from diabetic NOD mice


Mouse Genome Informatics
cx3
    Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0

NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• when mice are injected with islet-specific CD8+ T cells, 0/5 transgenic Fas-deficient mice become diabetic whereas 5/5 transgenic Fas-sufficient mice develop diabetes 5 days after transfer

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81416


Mouse Genome Informatics
tg4
    Tg(Ins2-Fasl)24Ach/0
NOD-Tg(Ins2-Fasl)24Ach
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• majority of mice develop diabetes by 10 weeks of age vs controls which develop diabetes by 12 weeks of age; diabetes determined as blood glucose greater than 250 mg/dl (J:78679)
• mice develop diabetes in ~ 5 days of transfer of diabetogenic T cells (J:81416)

endocrine/exocrine glands
• at 25 weeks of age, transgenic mice show significant islet damage with little remaining insulin

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:78679